12.13 Estimated GFR is Associated with Endothelium-Independent Vasodilation in the Forearm Microcirculation of Hypertens
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Vessels and Endothelium 12.13 Estimated GFR is Associated with Endothelium-Independent Vasodilation in the Forearm Microcirculation of Hypertensive Patients D. Versari (1), A. Virdis (1), L. Ghiadoni (1), E. Daghini (1), S. Masi (1), A. Magagna (1), A. Salvetti (1), S. Taddei (1) ` di Pisa, Pisa, Italy (1)Universita Introduction. The relation between endothelial and renal function in patients with normal or mildly reduced renal function is still controversial. Aim. To evaluate the relationship between the endothelium-dependent (EDV) and independent (EIV) vasodilation in the forearm microcirculation and the estimated glomerular filtration rate (eGFR) in a population of untreated hypertensive patients without previous cardiovascular (CV) events. Methods. 315 patients (age 24-78 years; 83% males; 19% smokers; LDL-cholesterol 138.4±31.8 mg/ dl; blood glucose 96.0±15.4 mg/dl) were recruited. eGFR was calculated by the Modification of Diet in Renal Disease formula. EDV and EIV were evaluated as maximal forearm vasodilation to intraarterial infusion of acetylcholine and sodium nitroprusside, respectively. Results. mean eGFR was 83.5±18.9 (range 51-132) ml/min and 71% of patients had eGFR
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