155 Quantification of pulse wave velocity in the pulmonary artery in patients with pulmonary hypertension
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Meeting abstract
155 Quantification of pulse wave velocity in the pulmonary artery in patients with pulmonary hypertension Javier Sanz*, Susanna Prat-Gonzalez, Frank Macaluso, Valentin Fuster and Mario Garcia Address: Mount Sinai School of Medicine, New York, NY, USA * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A56
doi:10.1186/1532-429X-10-S1-A56
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A56 © 2008 Sanz et al; licensee BioMed Central Ltd.
Introduction Pulmonary artery (PA) stiffness increases in pulmonary hypertension (PH). Pulse wave velocity (PWV) is an index of stiffness that provides prognostic information in systemic arterial disease, but its quantification in the pulmonary circulation is challenging. Harmonic analysis of the oscillatory variations in PA diameters and pressures measured invasively has been used in the past to determine that PWV is on average ~2 m/s in normal individuals and ~4.5 m/s in the presence of PH.
throughout the cardiac cycle and the cardiac index were measured from the phase-contrast images. Combining CMR and RHC data, pulmonary elastic modulus (EM) was calculated as: EM (mmHg) = pulse pressure/pulsatility; where pulse pressure = systolic - diastolic PA pressures (in mmHg); and pulsatility = (maximal PA area - minimal PA area)/minimal PA area (areas measured in cm2).
Purpose To evaluate the feasibility of measuring pulmonary PWV combining information obtained with cardiac magnetic resonance (CMR) and right heart catheterization (RHC).
PWV was quantified using the formula:
Methods
where ρ = blood density (assumed to be constant and equal to 1025 kg/m3).
CMR and RHC were performed on the same day in 94 patients with known or suspected PH. Systolic, mean and diastolic PA pressures, cardiac index (thermodilution) and pulmonary vascular resistance index (PVRI) were measured invasively. From the RHC results, patients were classified as those with (n = 75) or without PH at rest (n = 19), defined as mean PA pressure >25 mmHg. CMR evaluation included phase-contrast imaging perpendicular to the pulmonary trunk, using a segmented fast gradient echo sequence: TR 7.5 ms, TE 3.1 ms, slice thickness 6 mm, matrix = 256 × 96, 5–7 segments, 20 reconstructed cardiac phases, velocity encoding 100 cm/s. PA areas
PWV (m/s) = (133.28 × EM/2 × ρ)1/2;
Data are expressed as median (interquartile range) unless otherwise stated. A p value < 0.05 was considered significant. Statistical analyses were performed with SPSS 12.0©.
Results The median PWV in the study population was 3.7 m/s (range 1.1–6.3 m/s). CMR-derived pulsatility was inversely correlated with mean and s
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