2010 Delayed enhancement of the coronary artery vessel wall in patients with coronary artery disease at 3.0 Tesla
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Meeting abstract
2010 Delayed enhancement of the coronary artery vessel wall in patients with coronary artery disease at 3.0 Tesla Sebastian Kelle*1, Kelly Schlendorf1, Glenn A Hirsch1, Eckart Fleck2, Robert G Weiss1 and Matthias Stuber1 Address: 1Johns Hopkins University, Baltimore, MD, USA and 2German Heart Institute Berlin, Berlin, Germany * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A279
doi:10.1186/1532-429X-10-S1-A279
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A279 © 2008 Kelle et al; licensee BioMed Central Ltd.
Background Enhancement of the vascular wall after MRI contrast administration (Gd) has been reported in several inflammatory vasculopathies and in carotid atherosclerosis, where delayed enhancement (DE) has been associated with the plaque components, including the fibrous cap [1,2]. While no post contrast DE of the coronary vessel wall was found in young healthy adult subjects [4], coronary vessel wall DE has been reported in patients with coronary artery disease (CAD). All of these studies were performed at 1.5 T, a double or triple dose of Gd was injected, the time course of the process has not been well characterized [3,4] and as a result, MRI was performed up to 3 hrs after injection of the contrast agent [3].
Purpose Because high-field coronary MRI may offer higher sensitivity and spatial resolution, we sought to use 3 T MRI for coronary vessel wall DE imaging after low-dose contrast injection, and to study the optimal time interval for DE coronary vessel wall measurements in patients with established CAD.
Methods Eleven patients with a clinical history of CAD (5 male, 6 female, age 44–76 years, mean 61 ± 10 years) were studied on a 3.0 Tesla whole-body MR imaging system (Achieva 3 T; Philips, Best, The Netherlands). MR angiography of the right or left coronary artery system was performed with a navigator-gated free-breathing and cardiac-triggered, T2-
prepared, three-dimensional, segmented k-space, gradient-echo imaging sequence after administration of 0.1 mmol/kg Gd-DTPA (Magnevist®, Berlex Laboratories, Montville, New Jersey, USA). T1-weighted inversionrecovery coronary MRI at the same anatomical level was then repeated up to 75 minutes after contrast administration. The data were analyzed after segregation into three time intervals: 30–45 (time 1); 45–60 (time 2) and 61–75 (time 3) minutes post-contrast. The magnitude of DE in the coronary arteries as well as in the ascending and descending aortic vessel wall was evaluated using a 3point-scale (0 = no enhancement; 1 = mild to moderate enhancement; 2 = strong enhancement) and these categories were compar
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