2085 Strain encoded magnetic resonance imaging (SENC) assessment of regional ventricular function in pulmonary arterial
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BioMed Central
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Meeting abstract
2085 Strain encoded magnetic resonance imaging (SENC) assessment of regional ventricular function in pulmonary arterial hypertension – initial results Monda L Shehata*, Lynette Brown, Jens Vogel-Claussen, Joao AC Lima, Reda E Girgis, Paul M Hassoun, David A Bluemke and Nael F Osman Address: Johns Hopkins University, Baltimore, MD, USA * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A354
doi:10.1186/1532-429X-10-S1-A354
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A354 © 2008 Shehata et al; licensee BioMed Central Ltd.
Purpose
with catheterization established diagnosis of PAH (mean ± SD pulmonary artery pressure [PAP] = 34.25 ± 10.6 mm Hg). Both groups were scanned at 3 T MRI. Three shortaxis slices at the base, mid and apical regions were acquired for each subject. Image analysis was performed using custom software. Left ventricular Ell was quantified from six basal, six mid and four apical regions respectively. Ell in the RV free wall was measured at 5 equidistant segments starting from the anterior septal insertion and ending at the posterior septal insertion. At each segment, two measurements of Ell were averaged to calculate peak systolic Ell, defined from cine SENC and fSENC images as strain values at peak contraction. In our analysis, we excluded two suboptimal apical slices from volunteer group as well as two anterior right ventricular segments from patient group passing through RV out flow tract plane. Peak systolic Ell values of the LV and RV regions in patients were compared to corresponding regions in control group using unpaired Student-t test.
To analyze the effect of pulmonary arterial hypertension on myocardial strain using strain encoded MRI.
Results
Introduction Evaluation of right ventricular (RV) function is an important prognostic factor in many cardiac and/or pulmonary conditions. Pulmonary arterial hypertension (PAH) is a major cause of RV dysfunction and failure, which in turn affects left ventricular performance due to ventricular interdependence. Cardiac MRI is a reproducible three dimensional tomographic tool providing accurate measurements of global right ventricular function. For the RV, measuring regional strain using MRI (e.g., using tagging) is limited by thin wall. Strain encoded MRI (SENC), however, enables the quantification of RV strain (1) in the longitudinal direction (Ell), which is the main contributor to RV contractile function. On the other hand, fast strain encoded MRI (fSENC) allows for single heartbeat, non breath hold, acquisitions; thus providing an alternative to patients experiencing difficulty in breath holding (2).
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