2141 A novel approach for screening atherosclerosis in diabetes: MRI of the superficial femoral artery
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BioMed Central
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Meeting abstract
2141 A novel approach for screening atherosclerosis in diabetes: MRI of the superficial femoral artery Jamieson M Bourque*, Brian J Schietinger, Jamie L Kennedy, John M Christopher, Angela M Taylor, Colleen A McNamara and Christopher M Kramer Address: University of Virginia, Charlottesville, VA, USA * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A410
doi:10.1186/1532-429X-10-S1-A410
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A410 © 2008 Bourque et al; licensee BioMed Central Ltd.
Introduction
Results
Peripheral arterial disease (PAD) has a high prevalence (29%) in asymptomatic patients with diabetes mellitus (DM) with a significantly increased risk of cardiovascular events and morbidity. Current screening methods are inadequate. The superficial femoral artery (SFA) may be a relatively accessible target for screening of atherosclerosis. Cardiovascular magnetic resonance (CMR) allows direct visualization of atherosclerotic plaque burden noninvasively. We sought to establish the prevalence of peripheral atherosclerosis in a cohort of asymptomatic patients with diabetes and coronary artery disease by CMR of the SFA.
The cohort had similar age and gender compared with the controls (age ± standard deviation (SD) 63.9 ± 8.6 vs. 63.2 ± 9.3, p = 0.66, and gender 82%M versus 80%M, p = 0.88). Subjects had a duration of DM of 11 ± 8.9 years, with HgbA1c 7.6 ± 1.5 with 88% oral agent and 24% insulin use. There were 35.3% with prior PCI and 35.3% had prior coronary bypass surgery. Mean ± SD LDL was 73 ± 21 mg/dL, HDL 43 ± 12 mg/dL, and microalbumin 2.8 ± 6.8 mg. Compared to the controls, the DM-CAD cohort had a higher BMI (30.1 ± 2.9 vs. 24.6 ± 2.6; p < 0.001), more hypertension (94% vs. 20%, p < 0.001), tobacco use (53% vs. 30%, p < 0.001), and statin therapy (94% vs. 60%, p < 0.001). Thirty-five vessels were analyzed for the 18 subjects, 20 for the 10 controls. The length of SFA imaged was similar between the groups (16.5 ± 2.7 cm vs. 15.8 ± 2.9 cm, p = 0.42). Subjects with DM and CAD (Figure 1B) had greater WT (1.53 ± 0.29 mm vs. 1.18 ± 0.26 mm, p = 0.016) and higher IWV (52.0 ± 1.2% vs. 45.8 ± 7.0%, p < 0.001) than controls (Figure 1A).
Methods We studied 18 subjects with DM and CAD and no symptoms, manifestations, or history of PAD with 10 agematched controls without DM or known vascular disease. We collected extensive clinical information and performed ankle-brachial index (ABI) measurements. Patients with positive ABIs were excluded. CMR imaging of both lower extremities was performed utilizing a linear 4-element surface coil array on a 1.5 Tesla Siemens Avanto scanne
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