6.12 Elevated Serum Adiponectin Level is Associated with a Decrease in Rate of Proximal Tubular Sodium Reabsorption
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Kidney 6.12 Elevated Serum Adiponectin Level is Associated with a Decrease in Rate of Proximal Tubular Sodium Reabsorption A. Barbato,1 F. Galletti,1 R. Iacone,1 A. Siani,2 G. Barba,2 S. Avallone,1 A. Venezia,1 F.P. Cappuccio,3 P. Strazzullo1 ` di Napoli Federico II, (1) Dip. di Medicina Clinica e Sperimentale, Universita Napoli, It Italy; (2) Istituto di Scienze dell’Alimentazione, CNR, Avellino, It Italy; (3) Unit of Cardiovascular Medicine & Epidemiology, CSRI, Warwick Medical School, Coventry, UK UK Introduction: A decrease in adiponectin levels, an adipocyte specific plasma protein with antiatherogenic and antidiabetic properties, is associated to hypertension in both experimental and human models. The mechanisms underling this relation remain to be elucidated. Methods: The aim of this study was to study the relationship between adiponectin levels and tubular sodium handling evaluated by lithium clearance technique, in a group of 424 untreated male (mean age 51 yrs, range 26 to 73 yrs) participating at the Olivetti Heart Study. Results: Adiponectin levels are inversely associated to both systolic and diastolic blood pressure. Conclusions: Low adiponectin levels were associated to both an increase in proximal sodium tubular reabsorption and blood pressure, after adjustment for body weight and insulin-resistance.
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