8.4 Baroreflex Sensitivity Correlates with Left Ventricular Systolic function in Hypertensive Patients
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High Blood Press Cardiovasc Prev 2007; 14 (3): 145-196 1120-9879/07/0003-0145/$44.95/0 © 2007 Adis Data Information BV. All rights reserved.
Nervous System 8.4 Baroreflex Sensitivity Correlates with Left Ventricular Systolic Function in Hypertensive Patients M.A. Caserta, A. Milan, S. Del Colle, A. Dematteis, D. Naso, C. Magnino, E. Puglisi, A. Pertusio, F. Tosello, E. Saglio, S. Monticone, M.I. De Andres, F. Veglio ` di Torino, S.C.U. Medicina Interna 4, A.O. San Giovanni Battista, Universita Torino, Italy Introduction: Arterial hypertension (AH) causes systolic impairment measured by Midwall Fractional Shortening (MFS), but the mechanism underlying this phenomenon is not completely understood. Spontaneous baroreflex sensitivity (BRS) is a key mechanism for blood pressure homeostasis and it is impaired in hypertensive patients. The aim of our study was to evaluate the association between BRS and left ventricular (LV) systolic function. Methods: We studied 224 hypertensive patients (125 male; mean ± SD age, 47.8±10.8) compared to 42 normotensive control subjects (C) (age 43.6±12.5). Every subject underwent clinical evaluation, echocardiography with ultrasound systems (ATL 5000) equipped with multiple frequency phased array transducers (2 to 4 MHz) to study left ventricular morphology and function. Spontaneous BRS was non invasively assessed with Portapres. Results: BRS is significantly associated with left ventricular systolic function valuated with MFS (r 0.28 p=0.27, pp0.17, pp0.17 (see figure). Conclusion: Our results indicate a reliable association between of BRS control of heart rate and systolic dysfunction, suggesting that BRS assessment could be used as an alternative marker of systolic left ventricular impairment and as an additional tool for the stratification of cardiovascular risk in hypertensive patients.
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