9.8 New-Onset Diabetes and Uncontrolled Blood Pressure
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Metabolic Aspects and Mechanisms 9.8 New-Onset Diabetes and Uncontrolled Blood Pressure R. Izzo (1), G. de Simone (2), M. Chinali (2), R. Giudice (1), A. Vasta (1), I. Botta (2), C. S. Cimmino (1), S. Crispo (1), N. De Luca (1), B. Trimarco (1) (1)Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed ` di Napoli “Federico II”, Napoli; (2)Dipartimento di Immunologiche, Universita ` di Napoli “Federico II”, Napoli, Italy Medicina Clinica e Sperimentale, Universita Introduction. Based upon epidemiological studies, the hypothesis that hypertension may precede diabetes development has been derived. I n this context it is unknown how the blood pressure control may affect this behaviour. The study evaluates how the diabetes incidence varies depending on insufficient control of blood pressure due to inadequate antihypertensive treatment. Methods. 1754 patients affected by hypertension but not by diabetes have been retrospectively evaluated (age 54±11 years; 43% female). The patients were under treatment at the Hypertension Center of “Federico II” University of Naples for at least two years (average 3±1 years). According to guidelines, blood pressure has been considered recent uncontrolled above 140/90 mmHg (systolic/ diastolic). The diagnosis of Diabetes Mellitus has been established accordingly 1997 American Diabetes Association (ADA) guidelines. The analysis has been performed based on the last blood pressure measurement before the diabetes diagnosis was issued or, when diabetes diagnosis was not done, on the blood pressure measurement taken in the last control. Results. During hypertension treatment follow-up, blood pressure levels resulted well controlled in 1042 patients (C), while they were unsatisfactory controlled in 712 patients (41% of the considered population) despite antihypertensive therapy (NC). There was a significantly difference in age in the C group (53 ± 12 years of age) vs the NC (51 ± 11 years of age; P
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