Voltage-Gated Calcium Channels
oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar macological targets in the treatment of a variety of disorders, such as epi lepsy, hypertension, and pain. Voltage-gated calcium channels have there fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac tivity, the book delves into a provocative overview of the history of the cal cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat ing, permeation, modulation and interactions with members of the exo- totic machinery—contributed by both established leaders and rising stars in the field.
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Voltage-Gated Calcium Channels Gerald W. Zamponi, Ph.D. Department of Physiology and Biophysics University of Calgary Calgary, Alberta, Canada
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VOLIAGE-GATED CALCIUM CHANNELS Molecular Biology Intelligence Unit Landes Bioscience / Eurekah.com Kluwer Academic / Plenum Publishers Copyright ©2005 Eurekah.com and Kluwer Academic / Plenum Publishers All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system; for exclusive use by the Purchaser of the work. Printed in the U.S.A. Kluwer Academic / Plenum Publishers, 233 Spring Street, New York, New York, U.SA. 10013 http://www.wkap.nl/ Please address all inquiries to the Publishers: Landes Bioscience / Eurekah.com, 810 South Church Street Georgetown, Texas, U.SA. 78626 Phone: 512/ 863 7762; FAX: 512/ 863 0081 www.Eurekah.com www.landesbioscience.com Voltage-Gated Calcium Channels^ edited by Gerald W. Zamponi, Landes / Kluwer dual imprint / Landes scries: Molecular Biology Intelligence Unit ISBN: 0-306-47840-4 While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefiilly review and evaluate the information provided herein.
Library of Congress Cataloging-in-Publication Data Voltage-gated calcium channels / [edited by] Gerald W. Zamponi. p. ; cm. ~ (Molecular biology intelligence unit) Includes bibliographical references and index. ISBN 0-306-47840-4 1. Calcium channels. I. Zamponi, Gerald W. II. Series: Molecular biology intelligence unit (Unnumbered) [DNLM: 1. Calcium Channels. 2. Action Potentials. QH 603.154 V935 2005] QP535.C2V655 2005 6ir.0181~dc22 2004023413
CONTENTS Preface 1. Ca^* Chemistry, Storage and Transport in Biologic Systems: An Overview Tashi G, Kinjo and Paul P.M. Schnetkamp Why Ca^*: Unique Chemical and Physical Features Ca^* Evolution: A Rejection from Cytoplasm Ca^"^ Signaling and Storage: The Endoplasmic Recticulum The Role of Ca^^ widiin the ER ER Heterogeneity: Ca^"^ Tunneling Versus Ca^^ Compartmentalization Ca^^ Signaling and Storage: Mitochondria Mitochondrial Ca^^: Uptake Function and Effects Ca^"^ Buffering: Cytosolicand Lumenal Channels that Lead to an Increase in Cytosolic Ca^* Intracellular C
