A Bibliometric Analysis and Visualization of Current Research Trends in Chinese Medicine for Osteosarcoma
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hinese Journal of Integrative Medicine
Available online at link.springer.com/journal/11655 Journal homepage: www.cjim.cn/zxyjhen/zxyjhen/ch/index.aspx E-mail: [email protected]
Original Article
A Bibliometric Analysis and Visualization of Current Research Trends in Chinese Medicine for Osteosarcoma YIN Meng-chen1, WANG Hong-shen1,2, YANG Xi3, XU Chong-qing1, WANG Tao1, YAN Yin-jie1, FAN Zhao-xiang1, MA Jun-ming1, YE Jie1, and MO Wen1 Background:: To illustrate the research framework, overall knowledge structure, and development ABSTRACT Background trends of Chinese medicine (CM) treatment for osteosarcoma (OS) by using a bibliometric analysis and newly Methods:: Research datasets were acquired from the Web of Science (WOS) developed visualization tools. Methods database from January 1, 1980 to September 30, 2019. VOS viewer and Citespace software was used to analyze the data and generate visualization knowledge maps. Annual trends of publications, distribution of institutes, distribution of journals, citation and H-index status, co-authorship status, research hotspots Results:: A total of 223 publications in the WOS database met the and co-citation status were analyzed. Results requirement. The number of published articles showed a rise but the citation frequency and the H-index of China were relatively low. The cooperation between the countries, institutes and authors were relatively weak. Most publications were basic researches. Most of the previous researches focused on basic mechanisms of CM in treating OS, and therapy and improvement of dosage form may become a frontier in this research field. Conclusions:: Compared with other fields, the field of CM treatment for osteosarcome is still in infancy. The Conclusions distribution of researches is imbalanced and cooperation between countries, institutions and authors remains to be strengthened. Furthermore, basic research occupies an absolute dominant position, and the exploration of the molecular mechanism of CM in preventing and treating OS may become a key point in the future. KEYWORDS osteosarcoma, Chinese medicine, bibliometric analysis, visualization, research trends
Osteosarcoma (OS), a most common malignant tumor arising from the bone, accounts for 25%–35% of malignant bone tumors in children and young adults. OS has a very high mortality and disability rate, which brings heavy burdens to families and society. The combination of neoadjuvant chemotherapy and limb salvage surgery is the standard treatment of OS and has significantly improved survival of OS patients over the past decades. To date, the 5-year survival rate of OS patients has increased to 55%–70%.(1,2) OS is highly invasive, with metastasis occurring in about 30% of patients, the 5-year survival for patients with metastatic disease is only 20%.(3,4) However, a considerable number of patients are either insensitive or resistant to chemotherapy. In addition, patients are still facing with recurrence and risk of pulmonary metastasis that could lead to poor prognosis. Accordingly, it is ur
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