A diffusion tensor imaging study to compare normative fractional anisotropy values with patients suffering from Parkinso
- PDF / 3,261,417 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 93 Downloads / 187 Views
ORIGINAL PAPER
A diffusion tensor imaging study to compare normative fractional anisotropy values with patients suffering from Parkinson’s disease in the brain grey and white matter Rahul P Kotian 1
&
K Prakashini 2 & N Sreekumaran Nair 3
Received: 25 April 2020 / Accepted: 17 June 2020 # IUPESM and Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Diffusion tensor imaging (DTI) appears as a sensitive method to study Parkinson’s disease (PD) pathophysiology and severity. Fractional anisotropy (FA) value is one of the scalar derivatives of DTI used to find out anisotropy within a voxel in a tissue and used for determining white matter integrity in aging and neurodegenerative diseases. We studied DTI derived FA in early PD subjects as their routine MRI scans were normal. 40 patients with early PD and 40 healthy controls were employed to evaluate changes in microstructural white and grey matter in the brain’s using DTI derived FA values. Comparison of FA values in the brain’s white and grey matter of patients with PD and age matched controls at the corpus callosum, centrum semiovale, pons, putamen, caudate nucleus, substantia nigra, cerebral peduncles and cerebellar peduncles, was done using a region of interest (ROI) technique, with b-value 1000s/mm2 and TE = 100 milliseconds using 1.5 T MRI system. PD patients showed differences in FA values in both the grey and white matter areas of the brain’s compared to healthy controls. Our study revealed the presence of damage in the substantia nigra, corpus callosum, putamen and cerebral peduncles mainly in the PD group. Our findings indicate that DTI and region of interest (ROI) methods can be used in patients with early PD to study microstructural alterations mainly in the substantia nigra, putamen and corpus callosum. Keywords Fractional anisotropy . Diffusion tensor imaging . Parkinson’s disease . Magnetic resonance imaging . Neuroimaging
1 Introduction Parkinson’s disease (PD) is a dopamine related dysfunction and its diagnosis is made in the presence of at least one motor systems, such as, bradykinesia, rest tremor, rigidity and postural instability [1]. PD manifests within the brain very slowly
* Rahul P Kotian [email protected] K Prakashini [email protected] N Sreekumaran Nair [email protected] 1
Medical Imaging Technology, Department of Medical Imaging Technology, College of Allied Health Sciences, Srinivas University, Mukka Karnataka, India
2
Department of Radiodiagnosis and Imaging, Kasturba Medical College, MAHE, Manipal, India
3
Department of Statistics, MAHE, Manipal, India
and hence conventional MRI scans fail to pick any significant changes. However, MRI brain scans can show age related and atrophy changes but the overall diagnostic value in PD is poor. Early diagnosis in PD allows the clinicians to improve the quality of life and reduce morbidity of these PD patients. The search of a neuroimaging biomarker for early PD diagnosis is crucial and might have a high impact on a patient’s quality of life. Diffu
Data Loading...
