A head-to-head comparison of measurement properties of the EQ-5D-3L and EQ-5D-5L in acute myeloid leukemia patients
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A head‑to‑head comparison of measurement properties of the EQ‑5D‑3L and EQ‑5D‑5L in acute myeloid leukemia patients Hongjuan Yu1,2 · Xueyun Zeng3 · Mingjie Sui3 · Rui Liu3 · Rachel Lee‑Yin Tan4 · Jinjin Yang5 · Weidong Huang3 · Nan Luo4 Accepted: 14 September 2020 © Springer Nature Switzerland AG 2020
Abstract Purpose This study aimed to compare the measurement properties of EQ-5D-3L(3L) and EQ-5D-5L(5L) in patients with acute myeloid leukemia (AML) in China. Methods We consecutively recruited 168 patients with AML from three tertiary hospitals to complete two rounds of interviews using the two versions of the EQ-5D. We compared (i) the ceiling effect using the McNemar’s test, (ii) test–retest reliability using intraclass correlation coefficient (ICC) and Cohen’s weighted Kappa, (iii) convergent validity using Spearman’s rank correlation coefficient (r) and iv) discriminatory ability using F statistic and area under the receiver operating characteristics curve (AUROC) of the 5L and the 3L. Results The 5L descriptive system showed significantly lower ceiling effects in comparison to the 3L descriptive system (p 0.05 > 0.05 0.453 0.754 > 0.05
Ceiling and floor effect The ceiling and floor effects are shown in Table 2. The 5L descriptive system showed significant decrease in ceiling effect when compared with the 3L descriptive system (p
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