A low-field nuclear magnetic resonance DNA-hydrogel nanoprobe for bisphenol A determination in drinking water
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ORIGINAL PAPER
A low-field nuclear magnetic resonance DNA-hydrogel nanoprobe for bisphenol A determination in drinking water Jing-Yi Wang 1,2 & Qi-Yue Guo 2,3 & Zi-Yi Yao 2,3 & Na Yin 1,2 & Shu-Yue Ren 2 & Ye Li 2,3 & Shuang Li 2 & Yuan Peng 2 & Jia-Lei Bai 2 & Bao-An Ning 2 & Jun Liang 1 & Zhi-Xian Gao 2 Received: 11 December 2019 / Accepted: 29 April 2020 # Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract A low-field nuclear magnetic resonance (LF-NMR) DNA-hydrogel (LNDH) nanoprobe was designed for bisphenol A (BPA) determination. It consists of Fe3O4 superparamagnetic iron oxide nanoparticles (SPIONs) and a DNA-hydrogel technology. Fe3O4 SPIONs were encapsulated in the DNA-hydrogel to form an aggregated state. After adding BPA, the gel system transformed into a sol gel due to the target-aptamer specific binding. The coated gathered particles dispersed and thus, the relaxation time T2 declined. The LNDH nanoprobe was developed to realize a simple, sensitive, and effective BPA determination method without repeated magnetic separation steps. Under the optimal experimental conditions, the determination range of the LNDH biosensor was 10−2~102 ng mL−1 and the limit of determination was 0.07 ng mL−1. The LNDH nanoprobe was applied to two kinds of water samples (tap water and bottled water). The recovery ranged from 87.85 to approximately 97.87%. This strategy offered a new method to detect BPA by LF-NMR. It is also expected to be applicable in related fields of food safety determination, environmental monitoring, and clinical diagnosis. Keywords LF-NMR . DNA-hydrogel . Fe3O4 SPIONs . BPA
Introduction Endocrine-disrupting chemicals (EDCs) have gained increasing attention because of their potential impacts on human health [1]. EDCs can mimic the action of the hormone estrogen disturbing the estrogen-estrogen receptor binding process (hormonal pathways) [2] and causing possible health effects Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00604-020-04307-6) contains supplementary material, which is available to authorized users. * Jun Liang [email protected] * Zhi-Xian Gao [email protected] 1
State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China
2
Tianjin Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Institute of Environmental and Operational Medicine, Tianjin 300050, China
3
College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China
[3]. Bisphenol A (BPA) is a kind of EDCs and is commonly used in our daily household products or various kinds of packaging. It is a major kind of raw materials used to produce polycarbonate plastic, epoxy resin, thermal-resistant products, and health care products [4, 5]. The annual BPA production was estimated to be more than 5 million tons in 2015 [6]. Based on daily use conditions and their potential effects on human health, it is necessary to propose a sensitive, fast, a
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