A meta-analysis of the rate and related factors of glaucomatous optic nerve damage in patients with Glaucomatocyclitic C
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ORIGINAL PAPER
A meta-analysis of the rate and related factors of glaucomatous optic nerve damage in patients with Glaucomatocyclitic Crisis Huafang Guo . Wenqiang Zhang . Qian Ye
Received: 20 February 2020 / Accepted: 29 June 2020 © Springer Nature B.V. 2020
Abstract Purpose To systematic analysis of domestic and foreign literature on the incidence and related factors of glaucomatous optic nerve damage (GOND) in patients with Glaucomatocyclitic Crisis (PSS). Methods A computerized literature search was carried out in PubMed database, Wanfang Medical Database, China National Knowledge Infrastructure to collected domestic and foreign research studies on the incidence and related factors of glaucomatous optic nerve damage of Glaucomatocyclitic Crisis. Using Stata 15.1 software, select the indicators: incidence, gender, age, single/double eyes, duration of disease, and intraocular pressure (IOP) at onset for meta-analysis. OR (odds risk) was used as the effect variable for the binary variables, and mean difference was used as the effect variable for the continuous variables. The results are expressed by each effect amount and its 95% Confidence interval (CI). If there was heterogeneity among the original studies, a random effects model was used; otherwise, a fixed effects model was used. Results A total of 13 studies were included. The incidence of GOND in PSS was 0.251 (95%CI: 0.175–0.327). Three studies include the relevant
H. Guo · W. Zhang · Q. Ye (&) General Hospital of the Central Theater of the Chinese People’s Liberation Army, No. 627 Wuluo Road, Wuchang District, Wuhan 430070, Hubei, China e-mail: [email protected]
factor analysis and the results showed: there was a statistically significant difference in age, and duration of disease in PSS patients with/without GOND (p= 0.000, p=0.000), there was no statistical difference between the two groups in gender, single /double eyes, and IOP at onset (p=0.468, 0.053, 0.065). Conclusion Glaucomatocyclitic Crisis can cause glaucomatous optic nerve damage. GOND is more likely to occur in patients who are older, and have a long course of the disease. For such patients, special attention should be paid to the detailed examination of visual function and follow-up. Keywords Glaucomatocyclitic crisis · Glaucoma optic nerve damage · Meta-analysis
Introduction Glaucomatocyclitic Crisis was first described by Posner and Schlossman in 1948, also known as Posner–Schlossman syndrome (PSS) [1]; PSS is a special form of anterior uveitis with increased intraocular pressure(IOP). It is mainly seen in young adults between 20 and 50 years old. It is characterized by non-granulomatous anterior uveitis with marked increase in IOP. Most of them are monocular, which can be recurrent and self-limiting. In Posner–Schlossman’s first report on PSS, he believed that PSS has a good prognosis, short onset time, and rarely occurs glaucomatous optic disk damage after treatment. But
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Int Ophthalmol
of the nine cases reported by Posner for the fi
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