A multi-level developmental approach towards understanding adolescent mental health and behaviour: rationale, design and

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A multi‑level developmental approach towards understanding adolescent mental health and behaviour: rationale, design and methods of the LIFECOURSE study in Iceland Thorhildur Halldorsdottir1   · Alfgeir Logi Kristjansson2 · Bryndis Bjork Asgeirsdottir1 · Ingibjorg Eva Thorisdottir1 · Jon Sigfusson3 · Erla Maria Jonsdottir Tolgyes3 · Heiddis B. Valdimarsdottir1,4 · John Allegrante5 · Inga Dora Sigfusdottir1,3,5 Received: 21 February 2020 / Accepted: 10 November 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020

Abstract Purpose  Identifying and understanding modifiable risk and protective factors that can inform early detection and intervention to prevent adolescent emotional problems and harmful behaviours is among the most pressing modern-day public health challenges. This paper describes the rationale, objectives, methods, and anticipated outcomes of the LIFECOURSE study, a multi-level, bio-psychosocial prospective study designed to advance our understanding of factors that shape adolescent mental health and behaviour. Methods  Conducted by the Icelandic Centre for Social Research and Analysis at Reykjavik University, LIFECOURSE is a longitudinal population-based developmental study of Icelandic adolescents born in 2004. The study utilizes a comprehensive multi-informant assessment of individual, societal and biological factors measured across the lifespan. Data assembly and collection were conducted from 2016–2020 and utilize both retrospective and prospective data sources: (a) retrospective registry data assembled from seven national databases, (b) prospectively collected social surveys and (c) biomarker samples. Results  Of the 3914 eligible adolescents, 60.8% (n = 2378) provided informed parental consent and student assent to participate in the study, with approximately half of the participants being female (n = 1175, 49.4%) and the majority being born in the capital area (n = 1455; 61.2%). The coverage of available data from the national databases and participation in the social surveys ranged from 81.7 to 100%. Conclusions  Major gaps remain in our knowledge of how individual, societal and biological factors across the lifespan—from early life to adolescence—interact and shape the risk for emotional problems and harmful behaviours during adolescence. The LIFECOURSE study was designed to address this knowledge gap. Keywords  Adolescence · Bio-psychosocial model · Emotional problems · Delinquency · Stress · Substance abuse * Thorhildur Halldorsdottir [email protected]

Introduction

* Inga Dora Sigfusdottir [email protected]

Adolescence is a high-risk period for the onset of emotional problems and harmful behaviours [1, 2]. Often these problems arise when young people experience major stress and vulnerabilities in their lives and/or are the result of being born into adverse circumstances [3–9]. Although, quite a lot is known about the effects of stress, there are still major gaps in our knowledge, especially in relation to how stress affects physiological and emotion