A New Binary Matrix for Specific Detection of Mercury(II) Using Matrix-Assisted Laser Desorption Ionization Mass Spectro
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J. Am. Soc. Mass Spectrom. (2019) DOI: 10.1007/s13361-019-02324-1
RESEARCH ARTICLE
A New Binary Matrix for Specific Detection of Mercury(II) Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Hani Nasser Abdelhamid,1,2,3
Hui-Fen Wu1,2,3,4,5
1
Department of Chemistry, National Sun Yat-Sen University, 70, Lien-Hai Road, Kaohsiung, 80424, Taiwan Center for Nanoscience and Nanotechnology, National Sun Yat-Sen University, 70, Lien-Hai Road, Kaohsiung, 80424, Taiwan 3 Advanced Multifunctional Materials Laboratory, Department of Chemistry, Assiut University, Assiut, 71515, Egypt 4 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, Kaohsiung, 80708, Taiwan 5 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University, 70, Lien-Hai Road, Kaohsiung, 80424, Taiwan 2
Abstract. The development of simple, low-cost, and specific detection method for mercury (Hg(II)) ions in aqueous media using matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) is a challenge due to matrix interferences and acidity that destroy weak interactions. Herein, a new binary matrix consists of mefenamic acid, and thymine (T) is applied for simple and specific detection of Hg(II) in aqueous solution and blood sample. Mass spectra show metal-to-ligand ratio of 1:2 (Hg(II):T) in which Hg(II) ions are bound to two T molecules and two water molecules, i.e., [Hg(T)2(H2O)2]. The method is simple and fast, and requires cheap reagents. In addition, the spectra show extremely specific signals for Hg(II) ions and insignificant signals in case of other competing metal ions. The concept of our protocol can be applied for other metals. The new matrix may be used for the analysis of small molecules with minimal interferences peaks. Keywords: Mercury, Matrix-assisted laser desorption ionization mass spectrometry, Organic matrices, Mefenamic acid, Thymine, T-Hg-T Received: 26 February 2019/Revised: 29 June 2019/Accepted: 10 August 2019
Introduction
M
ercury (Hg) is a great threat for human and animals because it causes serious diseases/syndromes [1]. World Health Organization (WHO) stated that the maximum allowable level of inorganic mercury should be no more than
Electronic supplementary material The online version of this article (https:// doi.org/10.1007/s13361-019-02324-1) contains supplementary material, which is available to authorized users. Correspondence to: Hani Abdelhamid; e-mail: [email protected], Hui–Fen Wu; e-mail: [email protected]
6 ppb (30 nM) in drinking water. However, Environmental Protection Agency (EPA) reported that annual global mercury emissions from both natural and anthropogenic sources are in the range of 5000 to 8000 metric tons per year. The EPA reported 4-year long study on different species of fish from 76,559 lakes in 48 states of the USA. They found that 48% of the investigated lakes (36,422 lakes) exceeded maximum allowable level of mercury [2]. Thus, there is an ever-growing demand for analytical tools th
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