A novel high doxorubicin-loaded Fe 3 O 4 @void@ZnO nanocomposite: pH-controlled drug release and targeted antitumor acti
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A novel high doxorubicin-loaded Fe3O4@void@ZnO nanocomposite: pH-controlled drug release and targeted antitumor activity Chen Wang1, Hao Wen1, Hailing Guo1, Xueyan Wang1 Anjian Xie1,* 1
, Yuhua Shen1,*
, and
School of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, People’s Republic of China
Received: 11 January 2020
ABSTRACT
Accepted: 29 August 2020
A novel ferroferric oxide (Fe3O4)@void@zinc oxide (ZnO) nanocomposite was constructed through a template-assisted selective etching method. The experiment results showed that the magnetic saturation value of nanocomposite could reach to 44.07 emu g-1, indicating the favorable magnetic targeting function. The presence of the void endowed the nanocomposite with high drug doxorubicin (DOX) loading capacity (85.65 lg mg-1). The pH-sensitive drug release was realized due to the gating effect of ZnO, and the DOX release rates were 92.7%, 60.8% and 23.4% at the pH values of 5.0, 6.5 and 7.4, respectively (37 °C). Besides, the Fe3O4@void@ZnO-DOX exhibited desirable antitumor effects attributed to their cellular uptake and above advantages. Therefore, the Fe3O4@void@ZnO nanocomposite may serve as a promising drug carrier in cancer therapy and other biomedical applications.
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Springer Science+Business
Media, LLC, part of Springer Nature 2020
Introduction At present, cancer occurrence is increasing dramatically. Chemotherapy is the most common and effective treatment, as widely known, but limited by low selectivity and high metabolism of the antitumor drugs toward cancerous cells, which causes significant side effects and systemic toxicity [1]. Therefore, it is necessary to design an ideal drug carrier with excellent biocompatibility, targeting ability, high drug loading and controlled sustained release
performance. For this goal, researchers have made use of tumor microenvironment and external stimulus to protect drugs from premature degradation, enhance the aggregation of drugs in cancerous tissues, as well as ameliorate the therapeutic effect [2]. Internal trigger factors mainly include pH value [3], enzyme [4] and redox [5] trigger factors. Among these inducements, changing pH is certainly an effective strategy for the advantage of simple design and universal applicability, because the physiopathological pH values in tumor and inflammatory
Handling Editor: Annela M. Seddon.
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https://doi.org/10.1007/s10853-020-05184-3
J Mater Sci
tissues are more acidic than in blood and normal tissues. ZnO nanomaterials with low toxicity have shown great potential in biomedical areas [6, 7]. Because it can be degraded in the tumor acidic environment (the ZnO is stable at pH 7.4 but dissociated to zinc ions at pH \ 5.5) [8], which could cause the loaded antitumor drugs to be accurately released to the cancerous sites, and effectively kill the tumor cells, indicating that the ZnO can serve as ‘‘gatekeeper’’ to actualize pH-controlled drug release goal. Alternatively, external trigger stimuli mai
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