A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and
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ORIGINAL CONTRIBUTION
A nutrient‑wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study Nikos Papadimitriou1,5 · David Muller2 · Piet A. van den Brandt3 · Milan Geybels3 · Chirag J. Patel4 · Marc J. Gunter5 · David S. Lopez6,7 · Timothy J. Key8 · Aurora Perez‑Cornago8 · Pietro Ferrari5 · Paolo Vineis2,9 · Elisabete Weiderpass5 · Heiner Boeing10 · Antonio Agudo11 · María‑José Sánchez12,13,14 · Kim Overvad15 · Tilman Kühn16 · Renee T. Fortner16 · Domenico Palli17 · Isabel Drake18 · Anders Bjartell19,20 · Carmen Santiuste14,21 · Bas H. Bueno‑de‑Mesquita2,22,23,24 · Vittorio Krogh25 · Anne Tjønneland26,27 · Dorthe Furstrand Lauritzen27 · Aurelio Barricarte Gurrea14,28,29 · José Ramón Quirós30 · Pär Stattin31 · Antonia Trichopoulou32,33 · Georgia Martimianaki32 · Anna Karakatsani32,34 · Elin Thysell35 · Ingegerd Johansson36 · Fulvio Ricceri37 · Rosario Tumino38 · Nerea Larrañaga39 · Kay Tee Khaw40 · Elio Riboli2 · Ioanna Tzoulaki1,2 · Konstantinos K. Tsilidis1,2 Received: 1 July 2019 / Accepted: 29 October 2019 © The Author(s) 2019
Abstract Purpose The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR
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