A Pattern Approach to Lymph Node Diagnosis
While a pattern approach to diagnosis is taught and practiced with almost every other tissue or organ in the body, the lymph node remains a mystery to most residents starting out in pathology and those pathologists with limited experience in the area. A P
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A Pattern Approach to Lymph Node Diagnosis
Anthony S.-Y. Leong, MB, BS, MD, FRCPA, FRCPath, FCAP, FASCP, FHKAM (Pathol), Honorary FHKCPath, Honorary FRCPT Director, Pathology Laboratories, Sunway Medical Center, Petaling Jaya, Malaysia Professor of Pathology, Jeffrey Cheah School of Medicine, Monash University, Sunway Campus, Malaysia Formerly Medical Director, Hunter Area Pathology Service, Newcastle Professor and Chair, Discipline of Anatomical Pathology University of Newcastle, New South Wales, Australia
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Anthony S.-Y. Leong, MD Director Pathology Laboratories Sunway Medical Center Petaling Jaya Malaysia Professor of Pathology Jeffrey Cheah School of Medicine Monash University Sunway Campus Malaysia [email protected]
ISBN 978-1-4419-7175-3 e-ISBN 978-1-4419-7176-0 DOI 10.1007/978-1-4419-7176-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010935338 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface The development of sophisticated ancillary techniques for lymph node diagnosis has made hematopathology a specialized discipline in many developed countries. Immunohistology, electron microscopy, and molecular diagnostic techniques are expensive procedures and require specialized resources and technical skills, commodities that are not readily available in many laboratories other than those in large medical facilities. The general or community hospital pathologist is thus still required to make a histological diagnosis based on microscopic observations of the biopsied lymph node, or at least, to decide if the pathological changes represent a reactive or neoplastic process before referring the material for an expert opinion. Importantly, as the pathologist to first encounter the excised lymph node, he or she is responsible for triage of the specimen. This requires familiarity not only with the different technologies
