A position statement on kidney disease from powdered infant formula-based melamine exposure in Chinese infants
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EDITORIAL COMMENTARY
A position statement on kidney disease from powdered infant formula-based melamine exposure in Chinese infants Craig B. Langman & Uri Alon & Julie Ingelfinger & Märta Englund & Jeffrey M. Saland & Michael J. G. Somers & F. Bruder Stapleton & Nelson Orta Sibú & Pierre Cochat & William Wong & Felicia U. Eke & Lisa Satlin & Isidro Salusky
Received: 20 December 2008 / Accepted: 22 December 2008 / Published online: 7 February 2009 # IPNA 2009
Abstract Melamine, a man-made non-nutritive substance containing nitrogen, can falsely elevate measures of protein content in foodstuffs. Several manufacturers of powdered infant formula in China apparently added melamine to raise
the measured protein content and thereby exposed thousands of infants and young children to very high levels of melamine. Such exposure resulted in cases of acute kidney failure and nephrolithiasis. This Editorial from
C. B. Langman Feinberg School of Medicine, Northwestern University–Children’s Memorial Hospital, Chicago, IL, USA
N. O. Sibú Hospital de Niños Insalud/Universidad de Carabobo, Valencia, Venezuela
U. Alon Pediatric Nephrology, The Children’s Mercy Hospital, Kansas City, MO, USA
P. Cochat Département de Pédiatrie–Inserm U820, Centre de Référence des Maladies Rénales Héréditaires, Hôpital Edouard-Herriot and Université Lyon 1, Lyon, France
J. Ingelfinger Pediatric Nephrology, Massachusetts General Hospital, Boston, MA, USA M. Englund Sach’s Children’s Hospital, Karolinska Institutet, Stockholm, Sweden M. Englund Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden J. M. Saland : L. Satlin Department of Pediatrics, The Mount Sinai Medical Center, New York, NY, USA M. J. G. Somers Harvard Medical School and Children’s Hospital Boston, Boston, MA, USA F. B. Stapleton Department of Pediatrics, University of Washington School of Medicine and Seattle Children’s Hospital, Seattle, WA, USA
W. Wong Department of Nephrology, Starship Children’s Hospital, Park Road, Grafton, Auckland, New Zealand
F. U. Eke University of Port Harcourt, Port Harcourt, Nigeria
I. Salusky Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, CA, USA
C. B. Langman (*) Kidney Diseases, Children’s Memorial Hospital, 2300 Childrens Plaza #37, Chicago, IL 60614, USA e-mail: [email protected]
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members of the world-wide Pediatric Nephrology community provides a common-sense approach to the care of infants who may have been exposed to powdered infant formula in 2007–2008. Keywords Acute kidney failure . Infant nutrition . Nephrolithiasis . Poisoning
Introduction Widespread disease in infants and young children resulting from exposure to toxic substances in medication is not uncommon in the modern world [1]. In the latter part of 2008, news reports appeared—and Chinese government authorities confirmed—that some manufacturers had added melamine to powdered infant milk formulas in China from the latter parts of 2007 through most of 2008 in order to increase the appa
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