A prospective study of novel disease activity indices for ankylosing spondylitis
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Rheumatology International https://doi.org/10.1007/s00296-020-04662-w
INTERNATIONAL
OBSERVATIONAL RESEARCH
A prospective study of novel disease activity indices for ankylosing spondylitis T. G. Sundaram1 · Hafis Muhammed1 · Amita Aggarwal1 · Latika Gupta1 Received: 2 May 2020 / Accepted: 24 July 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract There is an ongoing quest for robust disease activity measures in Ankylosing spondylitis (AS). Thus, we prospectively validated two new disease activity indices, Simplified AS Disease Activity Score (SASDAS) and modified Juvenile Spondyloarthritis Disease Activity Score (JSpADA). Patients with AS were assessed for BASDAI, ASDAS and other outcome measures at baseline and 3 months. Comparisons were drawn between those with juvenile onset, early disease and peripheral involvement, with the rest. Fisher’s r to Z transformation was used to compare correlations. Receiver-operating characteristic (ROC) curves were used to calculate cutoffs for inactive, low, high and very high disease activity. Of the 107 patients (mean age—29 years) of 6-years long disease, 38.3% had a juvenile onset. SASDAS and modified JSpADA exhibited excellent correlation with BASDAI and ASDAS (all p
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