A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleedin
- PDF / 1,506,262 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 19 Downloads / 208 Views
CASE REPORT
Open Access
A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report Taojiang Chen4†, Qin Yang5† and Hongyu Duan1,2,3*
Abstract Background: SARS-CoV-2 is highly infectious and has been a significant public health threat. Despite typical manifestations of illness are dominated by respiratory symptom, some patients have concurrent gastrointestinal manifestations, including nausea, diarrhea, and vomiting. Massive gastrointestinal bleeding, however, has rarely been reported. Case presentation: We herein described a case of severe SARS-CoV-2 infected patient with several risk factors for poor prognosis, including male, hypertension, old age, mixed bacterial infection and multilobular infiltration on radiological imaging. After improvement of respiratory status, the onset of gastrointestinal bleeding occurred, probably resulting from direct viral invasion as evidenced by the positive findings for SARS-CoV-2 in the repeat stool specimens. Although aggressive resuscitation was administered, hematochezia was uncontrolled. The patient rapidly deteriorated, suffered from cardiac arrest, and expired. Conclusions: Digestive symptoms could be severe in SARS-CoV-2 infected patients, especially for the high-risk individuals with predisposing conditions. A more thorough protocol for preventing cross-infection through faecaloral transmission should be implemented in the process of patient care and infection control. Keywords: SARS-CoV-2, Coronavirus disease 2019, High-risk predisposing factors, Gastrointestinal bleeding
Background Since December 2019, SARS-CoV-2 has become a significant public health threat around the world. SARSCoV-2 is an enveloped, non-segmented, positive-sense RNA virus belonging to the beta genus of the coronavirus family. It has been shown to possess a strong * Correspondence: [email protected] † Taojiang Chen and Qin Yang contributed equally to this work. 1 Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China 2 Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, Chengdu, Sichuan, China Full list of author information is available at the end of the article
capability to infect humans through a binding of the viral S protein to angiotensin converting enzyme II (ACE2) on human cells [1]. Although most patients have mild symptoms and good prognosis, several predisposing factors including male, hypertension, old age, mixed bacterial infection and multilobular infiltration on radiological imaging have been proposed to be associated with poor outcomes [2]. Therefore, for the vulnerable individuals with aforementioned risk factors, prompt and effective management to interrupt disease progression is of crucial importance in reducing complications and mortality. Relevant experience, however, appears to be very limited in our knowledge.
© The Author(s). 2020 Open Access This article is
Data Loading...
