A simplified 4-parameter model of volumetric capnograms improves calculations of airway dead space and slope of Phase II
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ORIGINAL RESEARCH
A simplified 4‑parameter model of volumetric capnograms improves calculations of airway dead space and slope of Phase III Gabriel C. Motta‑Ribeiro1 · Marcos F. Vidal Melo2 · Frederico C. Jandre1 Received: 26 August 2019 / Accepted: 15 December 2019 © Springer Nature B.V. 2019
Abstract To evaluate a compact and easily interpretable 4-parameter model describing the shape of the volumetric capnogram, and the resulting estimates of anatomical dead space (VDAW) and Phase III (alveolar plateau) slope (SIII). Data from of 8 mildly-endotoxemic pre-acute respiratory distress syndrome sheep were fitted to the proposed 4-parameter model (4p) and a previously established 7-parameter model (7p). Root mean square error (RMSE) and Akaike information criterion (AIC), as well as V DAW and SIII derived from each model were compared. Confidence intervals for model’s parameters, V DAW and SIII were estimated with a jackknife approach. RMSE values were similar (4p: 1.13 ± 0.01 mmHg vs 7p: 1.14 ± 0.01 mmHg) in the 791 breath cycles tested. However, the 7p overfitted the curve and had worse AIC in more than 50% of the cycles (p
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