A systematic review of health state utility values for thyroid cancer
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REVIEW
A systematic review of health state utility values for thyroid cancer Rachel Houten1 · Nigel Fleeman1 · Eleanor Kotas1,2 · Angela Boland1 · Tosin Lambe1 · Rui Duarte1 Accepted: 7 October 2020 © The Author(s) 2020
Abstract Purpose Health state utility values are commonly used to inform economic evaluations and determine the cost-effectiveness of an intervention. The aim of this systematic review is to summarise the utility values available to represent the health-related quality of life (HRQoL) of patients with thyroid cancer. Methods Eight electronic databases were searched from January 1999 to April 2019 for studies which included assessment of HRQoL for patients with thyroid cancer. Utility estimates derived from multiple sources (EuroQol questionnaire 5-dimension (EQ-5D), time trade-off [TTO] and standard gamble [SG] methods) were extracted. In addition, utility estimates were generated by mapping from SF-36 and EORTC QLQ-30 to the EQ-5D-3L UK value set using published mapping algorithms. Results Searches identified 33 eligible studies. Twenty-six studies reported HRQoL for patients with differentiated thyroid cancer and seven studies for patients with general thyroid cancer. We identified studies which used different methods and tools to quantify the HRQoL in patients with thyroid cancer, such as the EQ-5D-3L, SF-36, EORTC QLQ-30 and SG and TTO techniques to estimate utility values. Utility estimates range from 0.205 (patients with low-risk differentiated thyroid cancer) to utility values approximate to the average UK population (following successful thyroidectomy surgery and radioiodine treatment). Utility estimates for different health states, across thyroid cancer sub-types and interventions are presented. Conclusion A catalogue of utility values is provided for use when carrying out economic modelling of thyroid cancer; by including mapped values, this approach broadens the scope of health states that can be considered within cost-effectiveness modelling. Keywords Health-related quality of life · Systematic review · Thyroid cancer · Utility values
Introduction Thyroid cancer is the most common type of endocrinerelated cancer [1]. There has been a continuous rise in the incidence of thyroid cancer over the last few decades in various countries worldwide [2]. In 2015, there were 3,528 new cases [3] of thyroid cancer in the UK, with incidence rates
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11136-020-02676-2) contains supplementary material, which is available to authorised users. * Rachel Houten [email protected] 1
Liverpool Reviews and Implementation Group, University of Liverpool, 2.06 Whelan Building, The Quadrangle, Brownlow Hill, Liverpool L69 3GB, UK
York Health Economics Consortium, University of York, York, UK
2
projected to rise by 74% between 2014 and 2035; this is equivalent to 11 cases per 100,000 people [4]. Thyroid cancers are divided into four main sub-types. Papillary (PTC) and follicular thyroid cancers
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