A systemic review and metaanalysis of postoperative outcomes in urgent and elective bowel resection in patients with Cro
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REVIEW
A systemic review and metaanalysis of postoperative outcomes in urgent and elective bowel resection in patients with Crohn’s disease Linnea Samsø Udholm 1 & Simon Ladefoged Rasmussen 1 & Thyge K. Madsbøll 1 & Mohammed Omairi 2 & Alaa El-Hussuna 1 Accepted: 9 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose The study examined whether urgency of surgical intervention affects postoperative outcomes in patients with Crohn’s disease (CD) undergoing bowel resection. Method The review was conducted according to a predefined, published study protocol in Prospero which is an international database of prospectively registered systematic reviews in health. The study reported according to PRIMSMA guidelines. We searched Embase and Pubmed for articles reporting postoperative outcome after urgent and elective surgery in patients with CD undergoing bowel resection. Primary outcome variable was 30-day overall postoperative complications while secondary outcome variables were intraabdominal septic complications (IASCs), mortality, reoperation, and readmission. Assessment of bias was performed using Newcastle-Ottawa score. Two authors independently extracted data on each study, patients, and outcome measures. Results The search identified 22 studies in which 955 patients underwent urgent surgeries while 6518 patients underwent elective surgeries. Based on the quality assessment, 19 studies were classified as having high risk of bias, one study as having a medium risk of bias and 2 studies as having low risk of bias (≥ 8 stars). Random-effect metaanalysis showed urgent surgery was associated with ~ 40% increase in overall complications compared to elective surgery (RR = 1.43, 95% CI [1.09; 1.87], p = 0.010). IASCs also increased in patients who had urgent surgery (RR = 1.44, 95% CI [1.08; 1.92], p = 0.013). No significant difference was shown in mortality and readmission rates. Conclusion Urgent bowel resection in patients with CD is associated with higher risk of overall postoperative complications and IASCs. Keywords Crohn’s disease . Surgery . Postoperative complications . Septic complications . Urgency
Introduction Medical treatment is the cornerstone in treating Crohn’s disease (CD). The risk of surgery at 1, 5, and 10 years after diagnosis of CD is 16.3%, 33.3%, and 46.6% respectively Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00384-020-03786-6) contains supplementary material, which is available to authorized users. * Alaa El-Hussuna [email protected] 1
Department of surgery, Aalborg University Hospital, Hobrovej 22, 9000 Aalborg, Denmark
2
Department of Emergency, Sydvestjysk Sygehus, Esbjerg, Denmark
[1]. It is still controversial whether medical treatment reduces the need for surgery in patients with CD [1–4] or not [5, 6]. The surgical treatment can either be urgent (unplanned) or elective (planned). Indications for urgent surgery are obstruction, perforation and bleeding [7–9], whereas elective surgery often is
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