A thermosensitive textile-based drug delivery system for treating UVB-induced damage
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ORIGINAL RESEARCH
A thermosensitive textile-based drug delivery system for treating UVB-induced damage Xiao-Zhu Sun . Na Wang
Received: 22 October 2019 / Accepted: 4 July 2020 Ó Springer Nature B.V. 2020
Abstract Ultraviolet radiation is one of the most dangerous sources of damage to skin and causes sunburn, erythema, photoaging, and photocarcinogenesis. Some passive drug delivery systems (DDSs) have been developed to treat skin damage. Nevertheless, there have been few studies on the application of intelligent DDSs to enhance the treatment of sunburn. In this paper, thermosensitive microgels were prepared by porous CaCO3 infiltrated by a thermoresponsive polymer, which was synthesized by grafting carboxyl-terminated poly (N-vinylcaprolactam) (PVCL-COOH) onto hydrolyzed chitosan. By means of the pad-dry-cure method, microgels were attached to cotton fabrics to develop a medical textile for drug
delivery. The results indicated that the microgels were deposited both on the fiber surface and in the space between the fibers. The loaded drug presented a thermoresponsive release profile, and the release mechanism also varied with temperature. After being treated with the medical textile, human keratinocyte HaCaT cells could be protected by inhibiting UVBinduced lactate dehydrogenase leakage and increasing the levels of superoxide dismutase and glutathione peroxidase (GSH-Px). Our study suggested that this thermosensitive microgel-finished cotton fabric can be used as an effective device for the treatment of UVBinduced damage.
X.-Z. Sun (&) Institute of Petrochemical Technology, Jilin Institute of Chemical Technology, Jilin 132022, People’s Republic of China e-mail: [email protected] N. Wang ENO Biotechnology Co. Ltd, Dalian 116034, People’s Republic of China
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Cellulose
Graphic abstract
Keywords Thermosensitive Porous microgel Drug-releasing textiles UVB-induced damage
Introduction The skin is the largest organ of the body, and it protects us from infection and allergy induced by pathogens and small particles. Skin aging is a complicated process and may be influenced by many factors. The most important factor is ultraviolet irradiation (Silva et al. 2014). UV light comprises UVA (320–400 nm), UVB (290–320 nm), and UVC (100–280 nm) radiation. Excessive or frequent exposure to ultraviolet radiation, particularly UVB radiation, is regarded as the main reason for most sunburn and skin damage. UVB-induced pain in sunburn tissue is mainly mediated by impairing the oxidant/antioxidant balance, which gives rise to an increase in the cellular levels of reactive oxygen species (ROS) (Fonseca et al. 2009). Apoptosis at high levels promoted by ROS could lead to significant damage to cell structures (Zorov et al. 2000). Under oxidative stress, skin cells generate SOD and GSH-Px to resist ROS-induced damage (Park et al. 2012). Curcumin (Cur), found in the rhizome of the plant Curcuma longa, is a natural yellow-orange polyphenol with a low molecular weight (Castro et al. 20
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