Absolute Resting 13 N-Ammonia PET Myocardial Blood Flow for Predicting Myocardial Viability and Recovery of Ventricular
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Teda International Cardiovascular Hospital Nuclear Medicine Department, Tianjin Medical University Clinical Cardiovascular Institute, Tianjin, China Nuclear Science and Engineering Institute, University of Missouri-Columbia, Columbia, MO
Received May 27, 2020; accepted Sep 14, 2020 doi:10.1007/s12350-020-02388-7
Objective. We aimed to evaluate the feasibility of resting myocardial blood flow (rMBF), quantified with dynamic 13 N-Ammonia (NH3) PET, for identifying myocardial viability and predicting improvement of left ventricular ejection fraction (LVEF) after coronary artery bypass grafting (CABG). Methods. Ninety-three patients with coronary artery disease (CAD) and chronic LVEF < 45%, scheduled for CABG, had dynamic 13NH3 PET and 18F-FDG PET imaging. The perfusion/metabolism polar maps were categorized in four patterns: normal (N), mismatch (M1), match (M2) and reverse mismatch (RM). The value of rMBF for identifying viable myocardium (M1, RM) and post CABG improvement of LVEF‡8% was analyzed by receiver operating characteristic (ROC) curves. Correlations of rMBF in segments to DLVEF post CABG were verified. Results. Mean rMBFs were significantly different (N=0.60±0.14; M1=0.44±0.07, M2=0.34±0.08, RM=0.53±0.09 ml/min/g, P
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