Accelerated Path to Cures
Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug develo
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Accelerated Path to Cures
Accelerated Path to Cures
Josep Bassaganya-Riera
Accelerated Path to Cures
Editor Josep Bassaganya-Riera Nutritional Immunology and Molecular Medicine Laboratory Biocomplexity Institute of Virginia Tech Blacksburg, VA USA Biotherapeutics Inc. Blacksburg, VA USA
ISBN 978-3-319-73237-4 ISBN 978-3-319-73238-1 (eBook) https://doi.org/10.1007/978-3-319-73238-1 Library of Congress Control Number: 2018940478 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer International Publishing AG part of Springer Nature. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
1 Introduction to Accelerated Path to Cures and Precision Medicine in Inflammatory Bowel Disease ���������������������������������������������� 1 Josep Bassaganya-Riera and Raquel Hontecillas 2 Computer-Aided Drug Discovery������������������������������������������������������������ 7 Pinyi Lu, David R. Bevan, Andrew Leber, Raquel Hontecillas, Nuria Tubau-Juni, and Josep Bassaganya-Riera 3 Preclinical Studies: Efficacy and Safety�������������������������������������������������� 25 Nuria Tubau-Juni, Raquel Hontecillas, Marion Ehrich, Andrew Leber, Victoria Zoccoli-Rodriguez, and Josep Bassaganya-Riera 4 From Nutritional Immunology to Drug Development���������������������������� 41 Meghna Verma, Raquel Hontecillas, Vida Abedi, Andrew Leber, Pinyi Lu, Nuria Tubau-Juni, and Josep Bassaganya-Riera 5 Development of Synthetic Patient Populations and In Silico Clinical Trials���������������������������������������������������������������������� 57 Ramin Zand, Vida Abedi, Raquel Hontecillas, Pinyi Lu, Nariman Noorbakhsh-Sabet, Meghna Verma, Andrew Leber, Nuria TubauJ
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