Acenocoumarol/simvastatin interaction
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Haematoma in an elderly patient: case report An 83-year-old patient [sex not stated], who was receiving acenocoumarol [route, dosage and indication not stated], received simvastatin 20mg [route and indication not stated] by mistake instead of atorvastatin. Her INR increased to over 6, and she developed a large haematoma on her left shin [time to reaction onset and patient outcome not stated]. Author comment: "When adding statins, quinolones or [proton-pump inhibitors] to patients receiving acecoumarol, more frequent monitoring and if necessary coumarine dosage modifying is recommended to prevent hemorrhages due to high INR." Gyorgyi ZP, et al. Acenocoumarol Interactions in Everyday Practice. 10th Congress of the European Association for Clinical Pharmacology and Therapeutics : abstr. P135, 26 Jun 2011. Available from: URL: http://www.eacpt2011.org 803058502 Hungary
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Reactions 13 Aug 2011 No. 1364
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