Active Immunization

Active immunization is the process of challenging an individual with a foreign substance called a vaccine for the purpose of inducing a protective immune response against a known pathogen. The active ingredient(s) included in a vaccine are the specific co

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23

Vaccines

Joseph Domachowske  •  Manika Suryadevara Editors

Vaccines A Clinical Overview and Practical Guide

Editors Joseph Domachowske Department of Pediatrics SUNY Upstate Medical University Syracuse, NY USA

Manika Suryadevara Department of Pediatrics SUNY Upstate Medical University Syracuse, NY USA

ISBN 978-3-030-58413-9    ISBN 978-3-030-58414-6 (eBook) https://doi.org/10.1007/978-3-030-58414-6 © Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Preface

Vaccines—A Clinical Overview and Practical Guide is organized into 3 parts. Part 1 begins with a review of the human response to infection including key definitions and general concepts important in the field of vaccinology. Next, detailed chapters on currently available strategies that provide passive and active immune protection against infectious diseases are presented, including descriptions for how these biologic products are produced. Given the complexity of the manufacturing processes used in vaccine production and the frequency with which questions arise regarding the presence of various additives and excipients found in vaccines, a full chapter has been dedicated to the topic. Part 1 concludes with a chapter outlining the regulatory processes and timelines needed for the development and testing of new vaccine candidates. Part 2 of the book includes separate chapters on each of the 35 infections that are currently vaccine preventable. The chapters are presented in alphabetical order according to disease. The reader will find that certain terms and concepts important to the study of vaccines appear in many or even all of the chapters. Familiarity with the definition of several of these t

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