Acute bilateral myopia induced by Triplixam: a case report
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(2020) 20:375
CASE REPORT
Open Access
Acute bilateral myopia induced by Triplixam: a case report Ruta Jaruseviciene*
and Ginte Sirvydyte
Abstract Background: Side effects of the systemic drugs used to treat eyes are not common. Triplixam is used to treat systemic hypertension and contains amlodipine, indapamide and perindopril arginine as active ingredients which might have induced the sudden myopia. The transient myopia with objective findings disappeared after the discontinuation of the drug. Case presentation: A 33-year-old male presented to the emergency department with a history of blurred vision in both eyes. Development of myopia, lens thickening, choroidal effusion and retinal striae at the macula with the increase in macular thickness was observed in both eyes. These symptoms cleared completely after the drug was discontinued. Myopisation could have been caused by lens thickening and changing its refractive index as a result of allergic or idiosyncratic reaction of the ciliary body. Retinal striae may be caused by the volume effect of the choroidal effusion. Conclusion: Our report describes the adverse effect of Triplixam, probably resulting from its ingredient indapamide. Although indapamide is a common drug used in the treatment of systemic hypertension, it is important for cardiologists, general practitioners and other physicians to be aware of the possible adverse effect of Triplixam. Keywords: Myopia, Sulphonamide, Triplixam, Transient, Sudden
Background Ocular side-effects induced by drugs are rare. Transient myopia induced by drugs has been reported to be caused by the ingestion of sulphonamide-derived drugs, such as methazolamide, sulfasalazine, indapamide, acetazolamide, hydrochlorothiazide, ethoxzolamide, psychotropic drugs, etc. [1]. In this paper a case of sudden vision blurring in a young male who used Triplixam is presented. Triplixam is a drug used to treat systemic hypertension that combines three active ingredients: amlodipine, indapamide and perindopril arginine. Indapamide is a sulphonamide-derived diuretic which might have induced the myopia. The transient myopia disappeared after the discontinuation of the drug. * Correspondence: [email protected] Center of Eye Diseases, Clinic of Ear, Nose, Throat and Eye Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
Case presentation A 33-year-old male presented to the emergency department with a history of blurred vision in both eyes. The patient started experiencing blurred vision in the morning after using a computer during the night before. The patient did not feel any pain or other symptoms and the patient had never worn glasses. The medical history of the patient revealed uncontrolled hypertension that had lasted for several years for which he had started taking medications recently. He was taking Triplixam (amlodipine 5 mg, indapamide 2.5 mg, perindopril arginine 5 mg) (Les Laboratoires Servier, France) once per day, prescribed by his physician for his systemic hypertension. He
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