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Lack of efficacy: case report In a single center retrospective observational cohort study (clinical data between January 2014 and December 2019 was collected) of 12 patients, a 74-year-old patient [sex not stated] was described who exhibited lack of efficacy with adalimumab, prednisolone and mycophenolate mofetil while being treated for serpiginous-like choroiditis [not all routes and dosages stated]. The patient, who was diagnosed with serpiginous-like choroiditis, received SC adalimumab with a loading dose of 80mg, 40mg one week after and subsequently 40mg every two weeks, mycophenolate mofetil, and prednisolone 15mg. Additionally, the patient received unspecified anti-vascular endothelial growth factor (VEGF) injections concomitantly. Despite treatment with mycophenolate mofetil, prednisolone and adalimumab. The patient presented with 3 relapses. Therefore, it was concluded that the adalimumab was ineffective and serpiginous-like choroiditis was refractory to treatment with prednisolone and mycophenolate mofetil (lack of efficacy). Subsequently, adalimumab was discontinued after 10 months. de Groot EL, et al. The efficacy of adalimumab in treating patients with central multifocal choroiditis. American Journal of Ophthalmology Case Reports 20: Dec 2020. 803518524 Available from: URL: http://doi.org/10.1016/j.ajoc.2020.100921

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Reactions 5 Dec 2020 No. 1833