Adapalene/benzoyl peroxide
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Adapalene/benzoyl peroxide Allergic contact dermatitis: 6 case reports Six women aged 19–45 years with acne vulgaris developed allergic contact dermatitis during topical administration of adapalene/benzoyl peroxide gel [Epiduo]. They had been applying adapalene 0.1%/benzoyl peroxide 2.5% gel once daily for the treatment of facial and/or chest acne. Between 7 and 21 days after the first application, they presented with a history of acute erythemo-vesicular eruptions on areas treated with the gel. Adapalene/benzoyl peroxide was discontinued, and topical corticosteroids were administered. Their skin eruptions resolved within a few days. All women had positive patch tests with benzoyl peroxide 1% and negative patch tests with adapalene 0.1%. Most patch tests with Epiduo gel "open", "as is" and diluted to 30 and 10% were also positive. Author comment: "Adapalene and BPO [benzoyl peroxide] are both irritant and the latter is also a weak allergan, hence the daily use of this combined treatment may enhance the risk of BPO sensitization." Bulinckx A, et al. Contact dermatitis to the combination gel of adapalene 0.1% and benzoyl peroxide (PBO) 2.5%. European Journal of Dermatology 22: 139-40, No. 803074140 1, Jan 2012 - Belgium
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Reactions 28 Jul 2012 No. 1412
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