Adenoviruses: Model and Vectors in Virus-Host Interactions Virion-St
After three volumes on adenoviruses in 1995 the past years have seen rapid progress in the field of adenovirus research. Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens.
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Current Topics in Microbiology and Immunology
Editors R. W. Compans, Atlanta/Georgia M. D. Cooper, Birmingham/Alabama· Y.lto, Singapore H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel· M. B. A. Oldstone, La Jolla/California S. Olsnes, Oslo· M. Potter, Bethesda/Maryland P. K. Vogt, La Jolla/California· H. Wagner, Munich
Springer-Verlag Berlin Heidelberg GmbH
W. DOERFLER P. BOHM (Eds.)
Adenoviruses: Model and Vectors in Virus-Host Interactions Virion-Structure, Viral Replication and Host -Cell Interactions
With 60 Figures and 8 Tables
i
Springer
Prof. Dr. WALTER DOERFLER
Institut fUr Klinische und Molekulare Virologie Universitat Erlangen-Nurnberg 91054 Erlangen, Germany
e-mail: [email protected] PETRA BOHM Institut fur Genetik Universitat zu Kaln Weyertall21 50931 Kaln, Germany
e-mail: [email protected] Cover Illustration by M. Hose! (this volume): Overexpression of the E4-0RF3 gene of Ad12 (C) or Ad2 (D) leads to the reorganization of the PML protein domains in BHK21 hamster cells. In untransfected cells (A) or in cells transfected with the pIRES2-EGFP vector (B), PML protein domains retain their spherical structures. All sucessfully transfected cells are green due to the expression of EGFP (enhanced expression of the green fluorescent protein). The PML protein is detectable by staining with primary anti-PML protein antibodies and secondary Cy3-anti mouse IgG. Bars designate magnifications. This figure was reproduced from Hosel et al. (200la) see Chapter 14.
ISSN 0070-217X ISBN 978-3-642-05517-1
ISBN 978-3-662-05597-7 (eBook)
DOI 10.1007/978-3-662-05597-7 Libraryof Congress Catalog Card Number 72-152360 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag Berlin Heidelberg GmbH. Violations are liable for prosecution under the German Copyright Law. http://www.springer.de
Springer-Verlag Berlin Heidelberg 2003 Originally published by Springer-Verlag Berlin Heidelberg New York in 2003 Softcover reprint of the hardcover 1st edition 2003
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Library of Congress Catalog Card Number 15-129lO The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover Design: Design & Production GmbH, Heidelberg Typesetting: Fotosatz-Service Kohler GmbH, Wtirzburg Production Editor: Christiane Messerschmidt, Rheinau 27/3020 5432 1 0 Printed on acid-free paper
Preface
After volumes 109, 110 ("The Molecular Bio
