Adhesion Molecules: Function and Inhibition
Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume g
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Series Editor Prof. Michael J. Parnham PhD Senior Scientific Advisor GSK Research Centre Zagreb Ltd. Prilaz baruna Filipovic´a 29 HR-10000 Zagreb Croatia Advisory Board G. Z. Feuerstein (Wyeth Research, Collegeville, PA, USA) M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)
Forthcoming titles: The Resolution of Inflammation, A.G. Rossi, D.A. Sawatzky (Editors), 2007 The Immune Synapse as a Novel Target for Therapy, L. Graca (Editor), 2007 Angiogenesis in Inflammation: Mechanisms and Clinical Correlates, M.P. Seed, D.A. Walsh (Editors), 2008 New Therapeutic Targets in Rheumatoid Arthritis, P.-P. Tak (Editor), 2008 Inflammatory Cardiomyopathy (DCM) – Pathogenesis and Therapy, H.-P. Schultheiß, M. Noutsias (Editors), 2008 Matrix Metalloproteinases in Tissue Remodelling and Inflammation, V. Lagente, E. Boichot (Editors), 2008 (Already published titles see last page.)
Adhesion Molecules: Function and Inhibition
Klaus Ley Editor
Birkhäuser Basel · Boston · Berlin
Editor Klaus Ley La Jolla Institute for Allergy & Immunology 9420 Athena Circle La Jolla, CA 92037 USA (valid from November 2007)
Library of Congress Control Number: 2007929896
Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de
ISBN 978-3-7643-7974-2 Birkhäuser Verlag AG, Basel – Boston – Berlin The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2007 Birkhäuser Verlag AG, P.O. Box 133, CH-4010 Basel, Switzerland Part of Springer Science+Business Media Printed on acid-free paper produced from chlorine-free pulp. TCF ' Cover design: Markus Etterich, Basel Cover illustration: see page 275. With friendly permission of Eric A. Severson Printed in Germany ISBN 978-3-7643-7974-2 987654321
e-ISBN 978-3-7643-7975-9 www.birkhauser.ch
Contents
List of contributors Preface
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vii
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xi
Capture and rolling Rodger P. McEver P-selectin glycoprotein ligand-1 (PSGL-1) . . . . . . . . . . . . . . . . . . . . . . . . .
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