Adjuvant Chemotherapy: An Option for Asian Patients Only?
Survival rates following curative resection for gastric cancer are higher in East Asia than in Europe and the US. The aggressive surgical approach adopted in East Asia may explain these observations. In Japan and Korea, gastrectomy with extended lymphaden
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Florian Otto Manfred P. Lutz •
Editors
Early Gastrointestinal Cancers
123
Editors Florian Otto Tumor- und Brustzentrum ZeTuP St. Gallen Switzerland
ISSN 0080-0015 ISBN 978-3-642-31628-9 DOI 10.1007/978-3-642-31629-6
Manfred P. Lutz Saarbrücken Germany
ISBN 978-3-642-31629-6
(eBook)
Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2012949069 Ó Springer-Verlag Berlin Heidelberg 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
Part I
Multimodal Approach to Colorectal Cancer
Clinically Relevant Study End Points in Rectal Cancer. . . . 1 Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 End Points in Phase I Trials . . . . . . . . . . . . . . . . . . . . . 3 End Points in Phase II Neoadjuvant Rectal Cancer Trials . 3.1 Pathological Parameters of Response . . . . . . . . . . 3.2 Imaging Response . . . . . . . . . . . . . . . . . . . . . . . 4 Endpoints in Phase III Trials . . . . . . . . . . . . . . . . . . . . . 4.1 Disease-Free Survival and Local Recurrence . . . . . 4.2 The Need for Long-Term Follow-Up . . . . . . . . . . 5 Discussion. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . .
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