Advanced myocardial characterization in hypertrophic cardiomyopathy: feasibility of CMR-based feature tracking strain an
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Advanced myocardial characterization in hypertrophic cardiomyopathy: feasibility of CMR-based feature tracking strain analysis in a case-control study Liping Yang 1 & Lingbo Zhang 2 & Shaodong Cao 3 & Chao Gao 3 & Hanshan Xu 1 & Tiantian Song 1 & Xiushi Zhang 1,4 & Kezheng Wang 1 Received: 3 August 2019 / Revised: 29 December 2019 / Accepted: 28 April 2020 # European Society of Radiology 2020
Abstract Objectives This study aimed to evaluate the feasibility and reproducibility of using cardiovascular magnetic resonance feature tracking (CMR-FT) for analysis of bi-ventricular strain and strain rate (SR) in hypertrophic cardiomyopathy (HCM) patients as well as to explore the correlation between right ventricular (RV) and left ventricular (LV) deformation. Methods A total of 60 HCM patients and 48 controls were studied. Global and segmental peak values of bi-ventricular longitudinal, circumferential, radial strain, and systolic SR were analyzed. Pearson analysis was performed to investigate the correlation of RV and LV deformation. Intra-observer and inter-observer reproducibility were also assessed. Results LV mass in the HCM group was significantly higher than that in the control group. LV end-systolic and end-diastolic volume and RV end-systolic and end-diastolic volume in the HCM group were all significantly lower than the correlated parameters in the control group (p < 0.001, respectively), whereas no statistical difference was found in ejection fraction (p > 0.05). Global longitudinal strain (GLS), global longitudinal strain rate (GLSR), global circumferential strain (GCS), global circumferential strain rate (GCSR), global radial strain (GRS), and global radial strain rate (GRSR) of the LV and RV were all significantly lower than the control group, and segmental strain and SR were also true (p < 0.001, respectively). Bi-ventricular strain and SR measurements were highly reproducible at both intra- and inter-observer levels. Additionally, Pearson analysis showed RV GCS, GLS, and GRS positively correlated with LV GCS, GLS, and GRS (r = 0.713, p < 0.001; r = 0.728, p < 0.001; r = 0.730, p < 0.001, respectively). Conclusions CMR-FT is a promising approach to analyze impairment of global and segmental myocardium deformation in HCM patients non-invasively and quantitatively. Key Points • CMR-FT allows for advanced myocardial characterization with high reproducibility. • As compared with controls, HCM patients have significant differences in CMR-FT strain analysis while ejection fraction was similar. • CMR-FT may serve as an early biomarker of HCM in subjects at risk. Keywords Cardiovascular magnetic resonance . Feature tracking . Hypertrophic cardiomyopathy
Liping Yang and Lingbo Zhang contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00330-020-06922-6) contains supplementary material, which is available to authorized users. * Xiushi Zhang [email protected]
2
Head-Neck and Oral Department, The 2nd Affiliated Hospital of Harbin Med
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