Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles
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ASSISTED REPRODUCTION TECHNOLOGIES
Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles Robert J. Carrasquillo 1,2 & Taylor P. Kohn 3 & Cengiz Cinnioglu 4 & Carmen Rubio 2 & Carlos Simon 2 & Ranjith Ramasamy 5 & Nasser Al-Asmar 2 Received: 28 January 2019 / Accepted: 26 July 2019 # Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Purpose To study the impact of advanced paternal age on embryo aneuploidy. Methods This is a multicenter international retrospective case series of couples undergoing assisted reproduction via in vitro fertilization using donor eggs to control for maternal factors and preimplantation genetic testing for aneuploidy via nextgeneration sequencing at Igenomix reproductive testing centers. The main outcome measure was the prevalence of embryo aneuploidy in egg donor cycles. Semen analysis data was retrieved for a small subset of the male patients. Results Data from 1202 IVF/ICSI egg donor cycles using ejaculated sperm (total 6934 embryos) evaluated using PGT-A between January 2016 and April 2018 in a global population across all Igenomix centers were included. No significant association was identified between advancing paternal age and the prevalence of embryo aneuploidy overall and when analyzing for each chromosome. There was also no significant association between advancing paternal age and specific aneuploid conditions (monosomy, trisomy, partial deletion/duplication) for all chromosomes in the genome. Conclusions This is the largest study of its kind in an international patient population to evaluate the impact of advancing paternal age on embryo aneuploidy. We conclude there is no specific effect of paternal age on the prevalence of embryo aneuploidy in the context of embryo biopsies from egg donor cycles. Keywords Advanced paternal age . Advanced maternal age . Aneuploidy . In vitro fertilization . Egg donor
Introduction In recent years, there has been growing interest in the study of advanced paternal age (APA) and its impact on male fertility
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10815-019-01549-z) contains supplementary material, which is available to authorized users. * Robert J. Carrasquillo [email protected] 1
Division of Urology, Beth Israel Deaconess Medical Center, 145 Rosemary Street, C-1, Needham, MA 02494, USA
2
Igenomix, Valencia, Spain
3
Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
4
Igenomix USA, Los Angeles, CA, USA
5
Department of Urology, University of Miami Health System, Miami, FL, USA
potential, reproductive success, and the health of offspring. This is of particular relevance as the age at which men and women choose to start families has become increasingly later than their parents due to a variety of sociocultural factors including increasing life expectancy, changing roles for women, advanced age at time of marriage, and improving access to a
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