Advances in Geroscience
This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the
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Advances in Geroscience
Advances in Geroscience
&ELIPE 3IERRA s 2ONALD +OHANSKI Editors
Advances in Geroscience
Editors Felipe Sierra Division of Aging Biology .ATIONAL )NSTITUTES OF (EALTH.ATIONAL Institute of Aging "ETHESDA -$ USA
2ONALD +OHANSKI Division of Aging Biology .ATIONAL )NSTITUTES OF (EALTH.ATIONAL Institute of Aging "ETHESDA -$ USA
)3". )3". E"OOK DOI 10.1007/978-3-319-23246-1 Library of Congress Control Number: 2015955267 3PRINGER #HAM (EIDELBERG .EW 9ORK $ORDRECHT ,ONDON Ú 3PRINGER )NTERNATIONAL 0UBLISHING 4HIS WORK IS SUBJECT TO COPYRIGHT !LL RIGHTS ARE RESERVED BY THE 0UBLISHER WHETHER THE WHOLE OR PART OF THE MATERIAL IS CONCERNED SPECIlCALLY THE RIGHTS OF TRANSLATION REPRINTING REUSE OF ILLUSTRATIONS RECITATION BROADCASTING REPRODUCTION ON MICROlLMS OR IN ANY OTHER PHYSICAL WAY AND TRANSMISSION OR INFORMATION STORAGE AND RETRIEVAL ELECTRONIC ADAPTATION COMPUTER SOFTWARE OR BY SIMILAR OR DISSIMILAR METHODOLOGY NOW KNOWN OR HEREAFTER DEVELOPED 4HE USE OF GENERAL DESCRIPTIVE NAMES REGISTERED NAMES TRADEMARKS SERVICE MARKS ETC IN THIS PUBLICATION DOES NOT IMPLY EVEN IN THE ABSENCE OF A SPECIlC STATEMENT THAT SUCH NAMES ARE EXEMPT FROM THE RELEVANT PROTECTIVE LAWS AND REGULATIONS AND THEREFORE FREE FOR GENERAL USE 4HE PUBLISHER THE AUTHORS AND THE EDITORS ARE SAFE TO ASSUME THAT THE ADVICE AND INFORMATION IN THIS BOOK ARE BELIEVED TO BE TRUE AND ACCURATE AT THE DATE OF PUBLICATION .EITHER THE PUBLISHER NOR THE AUTHORS OR THE EDITORS GIVE A WARRANTY EXPRESS OR IMPLIED WITH RESPECT TO THE MATERIAL CONTAINED HEREIN OR FOR ANY ERRORS OR OMISSIONS THAT MAY HAVE BEEN MADE Printed on acid-free paper 3PRINGER )NTERNATIONAL 0UBLISHING !' 3WITZERLAND IS PART OF 3PRINGER 3CIENCE "USINESS -EDIA (WWWSPRINGERCOM
Foreword
)N AN INTRODUCTION TO A SPECIAL ISSUE OF 3CIENCE ;= MY COLLEAGUES AND ) EMPHASIZED THAT h7E HAVE FOCUSED ON PHYSIOLOGICAL MECHANISMS UNDERLYING PROCESSES OF AGING RATHER THAN ON THE LARGE ARRAY OF DEBILITATING AND COSTLY DISORDERS THAT SO COMMONLY EMERGE DURING THE LATTER HALF OF THE LIFE SPANS OF HUMAN BEINGSv 4HAT WAS BEFORE THE DAYS OF 'EROSCIENCE HOWEVER "UT WHAT EXACTLY is Geroscience? )T IS A TERM COINED BY MY COLLEAGUE AND FRIEND 'ORDON ,ITHGOW A PROFESSOR AT THE "UCK )NSTITUTE FOR 2ESEARCH ON !GING WHO TRUE TO HIS 3COTTISH HERITAGE IS THRIFTY WITH THE USE OF ALL INSTRUMENTS OF COMMERCE INCLUDING TERMINOLOGY 'ORDON USED THAT NOMENCLATURE TO SUMMARIZE A NEW INTERDISCIPLINARY RESEARCH ENTERPRISE AT THE "UCK #ENTER ALTHOUGH IT NEEDS SOME GRAMMATICAL EDITING IT IS QUITE INFORMATIVE h7E CONSIDER THAT THE RELATIONSHIP BETWEEN AGING AND AGE RELATED DISEASE IS AN IMPORTANT PROBLEM THAT CAN BE TACKLED THROUGH AN INTERDISCIPLINARY APPROACHv (HTTPWWWGEROSCIENCEONLINEORGINDEXPHP 4HIS VIEW EMPHASIZES THE CONCEPT THAT IT IS NOT ONLY DIFlCULT TO DISASSOCIATE FUNDAMENTAL PROCESSES OF AGING FROM THE NUMEROUS DISEASES OF AGING BUT THAT JOINT INVESTIGATIONS OF THESE TWO DOMAINS OF SCHOLARSHIP ARE ESSENTIAL IF WE ARE TO UNRAVE
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