Adverse Drug Reaction Update
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Adv Drug React Toxicol Rev 2002; 21 (1-2): 113-120 0964-198X/02/0001-0113/$25.00/0 © Adis International Limited. All rights reserved.
Adverse Drug Reaction Update Contents Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1. Ritonavir: Hepatotoxicity in HIV and Viral Hepatitis Infection . . . . . . . . 2. NSAIDs Associated with Relapse of Heart Failure . . . . . . . . . . . . . . . 3. Benzodiazepines: Risks During Pregnancy and Lactation . . . . . . . . . . 4. Antipsychotics: Risk of Sudden Cardiac Death . . . . . . . . . . . . . . . . 5. SSRIs and Extrapyramidal Syndromes . . . . . . . . . . . . . . . . . . . . . . 6. MMR Vaccine: ‘Safe’ in Most Children . . . . . . . . . . . . . . . . . . . . . 7. Dopamine Agonists: Sudden-Onset of Sleep Without Warning is Infrequent 8. Statins: Risk of Fatal Rhabdomyolysis . . . . . . . . . . . . . . . . . . . . . . 9. Paracetamol-Induced Liver Failure: Lactate Levels Predict Mortality? . . . 10. Antiasthmatics: Unmasking Symptoms of Churg-Strauss Syndrome? . . . . 11. Antiretrovirals: Mitochondrial DNA Levels a Marker of Toxicity . . . . . . . . 12. Trastuzumab: Increased Risk of Cardiac Dysfunction . . . . . . . . . . . . . 13. Maternal in utero Diethylstilbestrol Increases Hypospadias in Offspring . . 14. Unexpected Toxicity with Combined Interferon-α-2a and Thalidomide . .
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Increasing numbers of articles on adverse drug reactions are published in a wide range of medical journals. To help keep you up-to-date with the latest advances worldwide on all aspects of adverse drug reactions, this section of the journal brings you information selected from the drug safety alerting service Reactions Weekly1. The following reports are selected from the latest issues, summarising the most important clinical studies, adverse reaction news, and expert opinion pieces published across a broad range of literature sources.
1. Ritonavir: Hepatotoxicity in HIV and Viral Hepatitis Infection Ritonavir is associated with a higher incidence of hepatotoxicity than other protease inhibitors (PIs) among patients with comorbid HIV and viral hepatitis infection, according to researchers from Italy. Their retrospective study evaluated the oc-
currence of hepatotoxicity and the role of hepatitis viruses in its development, and included 1325 patients with HIV infection who had been treated with antiretroviral therapy for ≥6 months. The incidence of hepatotoxicity was significantly higher in patients with comorbid viral hepatitis infection, compared with those with HIV infection alone; viral
1 Reactions Weekly is the complete drug safety alertin
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