Adverse events of video capsule endoscopy over the past two decades: a systematic review and proportion meta-analysis
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RESEARCH ARTICLE
Open Access
Adverse events of video capsule endoscopy over the past two decades: a systematic review and proportion meta‑analysis Yuan‑Chen Wang1†, Jun Pan1†, Ya‑Wei Liu2†, Feng‑Yuan Sun1, Yang‑Yang Qian1, Xi Jiang1, Wen‑Bin Zou1, Ji Xia1, Bin Jiang1, Nan Ru1, Jia‑Hui Zhu1, En‑Qiang Linghu2*, Zhao‑Shen Li1 and Zhuan Liao1*
Abstract Background: A full spectrum of video capsule endoscopy (VCE) adverse events over the past two decades has not been evaluated. We aimed to determine pooled rates, predictors and temporal-trend of VCE adverse events over the past two decades. Methods: Systematic search of PubMed and EMBASE for English-language publications reporting VCE adverse events (January 1, 2000 to March 31, 2019). Data were extracted independently by two investigators. Pooled VCE adverse event rates were calculated using the random or fixed model as appropriate. Predictors and temporal-trend of each adverse event were performed by meta-regression analyses. Results: In total, 402 studies were identified, including 108,079 VCE procedures. Rate of retention, swallow disorder, aspiration, technical failure, and procedural adverse events were 0.73% (95% confidence interval [CI] 0.59–0.89%), 0.75% (95% CI 0.43–1.13%), 0.00% (95% CI 0.00–0.00%), 0.94% (95% CI 0.65–1.28%), 0.67% (95% CI 0.32–1.10%), respectively; incomplete examination rate of esophagus, stomach, small bowel, and colon were 9.05%, 7.69%, 12.08%, 19.19%, respectively. Patency capsule reduced retention rate by 5.04%, whereas known inflammatory bowel disease increased retention rate by 4.29%. Elder was the risk and protective factor for small bowel incomplete examination (0.30%) and swallow disorder (− 0.72%), respectively. Rates of retention and small bowel incomplete examination significantly declined over time (P = .0006 and P
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