Aging and Age-Related Disorders
Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and ab
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Editor-in-Chief Donald Armstrong
For other titles published in this series, go to http://www.springer.com/series/8145
Note from the Editor-in-Chief All books in this series illustrate point-of-care testing and critically evaluate the potential of antioxidant supplementation in various medical disorders associated with oxidative stress. Future volumes will be updated as warranted by emerging new technology, or from studies reporting clinical trials. Donald Armstrong Editor-in-Chief
Stephen Bondy · Kenneth Maiese Editors
Aging and Age-Related Disorders
Editors Stephen Bondy Department of Medicine Community & Environmental Medicine Center for Occupational & Environmental Health University of California, Irvine Room 320, Med Surge II lrvine CA 92697 USA [email protected]
Kenneth Maiese Department of Neurology and Neurosciences University of Medicine & Dentistry of New Jersey New Jersey Medical School Medical Science Building Room H-506 185 South Orange Avenue Newark NJ 07101 USA [email protected] [email protected]
ISBN 978-1-60761-601-6 e-ISBN 978-1-60761-602-3 DOI 10.1007/978-1-60761-602-3 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010932403 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
Some of the features that characterize the aging process include the gradual accumulation of damage to cells consequent to prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions that often cannot be resolved, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced in the chronic and slow-progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer’s disease and vascular diseases becomes sufficiently prevalent in the extreme elderly so that these disorders can arguably be considered “normal.” The chapters of this volume examine the interface between normal and pathologic aging and illustrate how this border can sometimes be diffuse. In organs with a very low rate of cell division such as cardiac and nervous tissues, the immune “memory” o
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