Aging and disease-relevant gene products in the neuronal transcriptome of the great pond snail ( Lymnaea stagnalis ): a
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SHORT COMMUNICATION
Aging and disease‑relevant gene products in the neuronal transcriptome of the great pond snail (Lymnaea stagnalis): a potential model of aging, age‑related memory loss, and neurodegenerative diseases István Fodor1 · Péter Urbán2 · György Kemenes3 · Joris M. Koene4 · Zsolt Pirger1 Received: 6 March 2020 / Accepted: 6 May 2020 © The Author(s) 2020
Abstract Modelling of human aging, age-related memory loss, and neurodegenerative diseases has developed into a progressive area in invertebrate neuroscience. Gold standard molluscan neuroscience models such as the sea hare (Aplysia californica) and the great pond snail (Lymnaea stagnalis) have proven to be attractive alternatives for studying these processes. Until now, A. californica has been the workhorse due to the enormous set of publicly available transcriptome and genome data. However, with growing sequence data, L. stagnalis has started to catch up with A. californica in this respect. To contribute to this and inspire researchers to use molluscan species for modelling normal biological aging and/or neurodegenerative diseases, we sequenced the whole transcriptome of the central nervous system of L. stagnalis and screened for the evolutionary conserved homolog sequences involved in aging and neurodegenerative/other diseases. Several relevant molecules were identified, including for example gelsolin, presenilin, huntingtin, Parkinson disease protein 7/Protein deglycase DJ-1, and amyloid precursor protein, thus providing a stable genetic background for L. stagnalis in this field. Our study supports the notion that molluscan species are highly suitable for studying molecular, cellular, and circuit mechanisms of the mentioned neurophysiological and neuropathological processes. Keywords Mollusc · Lymnaea stagnalis · cDNA sequencing · Aging · Neurodegenerative diseases
Introduction
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10158-020-00242-6) contains supplementary material, which is available to authorized users. * Zsolt Pirger [email protected] 1
NAP Adaptive Neuroethology, Department of Experimental Zoology, Balaton Limnological Institute, Centre for Ecological Research, Tihany 8237, Hungary
2
Genomics and Bioinformatics Core Facilities, Szentágothai Research Centre, University of Pécs, Pécs 7624, Hungary
3
Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK
4
Department of Ecological Science, Faculty of Science, Vrije Universiteit, Amsterdam, The Netherlands
Neuroscience research has been using molluscan species since the 1950s, when neuroscientists such as Nobel Prize laurates Alan Hodgkin, Andrew Huxley and Eric Kandel recognized how useful they can be in answering fundamental neurobiological questions. Such attractive and even today frequently used molluscan species are the sea hare (A. californica) and the great pond snail (L. stagnalis). For a long time, they were used for examining the neuronal processes from molecular s
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