Alemtuzumab
- PDF / 141,783 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 9 Downloads / 176 Views
1
S
Haematological disorders, opportunistic infections and fevers: 3 case reports Three patients with angioimmunoblastic T-cell lymphoma (AITL) developed opportunistic infections, fevers and haematological disorders during treatment with alemtuzumab. A 73-year-old woman commenced IV alemtuzumab 30mg three times weekly in June 2007, after previous chemotherapy regimens were unsuccessful. Prophylaxis was also initiated with cotrimoxazole [trimethoprim/ sulfamethoxazole], fluconazole and aciclovir. She developed fevers within 3 weeks, and reactivated cytomegalovirus was confirmed. Alemtuzumab was continued for 1 week with concomitant valganciclovir. CMV was suppressed successfully, but she subsequently developed neutropenia and thrombocytopenia. In June 2009, alemtuzumab was restarted with prednisone for a AITL relapse. She developed febrile neutropenia and CMV, and subsequently died of disease progression. A 73-year-old man, who had previously received chemotherapy, started a 7-week course of IV alemtuzumab 30mg thrice weekly in June 2007 for relapsed AITL. Pancytopenia developed 3 months after completing treatment, followed by agranulocytosis. Treatment with immune globulin was successful. He also developed aspergillus pneumonia [time to reaction onset not stated], which was also successfully managed. A 62-year-old woman received a 6-week course of IV alemtuzumab 30mg three times weekly after previous chemotherapy was ineffective. Famciclovir prophylaxis was also initiated. Fevers developed and reactivated CMV was confirmed [time to reaction onset not stated]. Valganciclovir was started, but further complications included pancytopenia and legionella pneumonia. Pancytopenia spontaneously resolved, and her other symptoms were managed appropriately. Amengual JE, et al. Sustained, durable responses with alemtuzumab in refractory angioimmunoblastic T-cell lymphoma. Leukemia and Lymphoma 51: 1347-1350, No. 7, Jul 2010. Available from: URL: http:// 803034176 dx.doi.org/10.3109/10428194.2010.486091 - USA
0114-9954/10/1315-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Reactions 21 Aug 2010 No. 1315
Data Loading...
