• PDF / 170,069 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 33 Downloads / 173 Views

DOWNLOAD

REPORT

---

1 S

Stevens-Johnson syndrome, toxic epidermal necrolysis: case report A 47-year-old man developed Stevens-Johnson syndrome (SJS) following administration of allopurinol for hyperuricaemia and toxic epidermal necrolysis (TEN) following administration of piroxicam for an acute gout attack [dosages and routes not stated]. The man presented to hospital in June 2018 with a 10-day history of a maculo-papular rash and erythema multiforme, which developed on his face and then spread to the trunk, arms and legs, along with oral mucosal erosion. He had been diagnosed with hyperuricaemia and allopurinol was prescribed for eight days prior to the presentation. Upon hospitalisation, he was diagnosed with SJS. The man was treated with methylprednisolone, immune globulin and supportive therapy. Skin and mucosal lesions improved well. On day 15, he was discharged. However, in January 2020, he presented again to emergency department from another local hospital due to a seven-day history of blister and desquamation. Although, he was treated with methylprednisolone and immune globulin at the local hospital, rapid progression of the lesions was noted. Upon presentation, the blisters and desquamation had developed globally along with severe conjunctiva, oral and genital mucosal erosion. He exhibited more than 60% epidermal detachment. Nine days prior to the presentation, he had received piroxicam for an acute gout attack. He was diagnosed with TEN and promptly admitted. He was treated with methylprednisolone, etanercept and supportive therapy. After 16-days of hospitalization, progressive full re-epithelisation of skin lesions was noted, and he was discharged. Findings of an IFN-γELISPOT assay were consistent with allopurinol-induced SJS and piroxicam-induced TEN. Xiong H, et al. Recurrence of Stevens-Johnson syndrome/toxic epidermal necrolysis induced by allopurinol and piroxicam. European Journal of Dermatology 30: 620-621, No. 5, Sep-Oct 2020. Available from: URL: http://doi.org/10.1684/ejd.2020.3857 803520401

0114-9954/20/1834-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved

Reactions 12 Dec 2020 No. 1834