Altered gray matter structural covariance networks at both acute and chronic stages of mild traumatic brain injury
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ORIGINAL RESEARCH
Altered gray matter structural covariance networks at both acute and chronic stages of mild traumatic brain injury Jie Song 1,2,3 & Jie Li 4 & Lixiang Chen 1,2,3 & Xingqi Lu 4 & Senning Zheng 1,2,3 & Ying Yang 4 & Bolin Cao 1,2,3 & Yihe Weng 1,2,3 & Qinyuan Chen 1,3,5 & Jianping Ding 4,6 & Ruiwang Huang 1,2,3
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Cognitive and emotional impairments observed in mild traumatic brain injury (mTBI) patients may reflect variances of brain connectivity within specific networks. Although previous studies found altered functional connectivity (FC) in mTBI patients, the alterations of brain structural properties remain unclear. In the present study, we analyzed structural covariance (SC) for the acute stages of mTBI (amTBI) patients, the chronic stages of mTBI (cmTBI) patients, and healthy controls. We first extracted the mean gray matter volume (GMV) of seed regions that are located in the default-mode network (DMN), executive control network (ECN), salience network (SN), sensorimotor network (SMN), and the visual network (VN). Then we determined and compared the SC for each seed region among the amTBI, the cmTBI and the healthy controls. Compared with healthy controls, the amTBI patients showed lower SC for the ECN, and the cmTBI patients showed higher SC for the both DMN and SN but lower SC for the SMN. The results revealed disrupted ECN in the amTBI patients and disrupted DMN, SN and SMN in the cmTBI patients. These alterations suggest that early disruptions in SC between bilateral insula and the bilateral prefrontal cortices may appear in amTBI and persist into cmTBI, which might be potentially related to the cognitive and emotional impairments. Keywords Mild traumatic brain injury (mTBI) . Structural covariance (SC) . Gray matter volume (GMV)
Jie Song and Jie Li contributed equally to this work. Highlights • The amTBI patients showed lower SC within the ECN than the controls. • The cmTBI patients showed higher SC within both the DMN and SN, but lower SC within the SMN, than the controls. • Altered SC for the DMN, ECN and SN was related to cognitive and emotional impairments in mTBI patients. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11682-020-00378-4) contains supplementary material, which is available to authorized users. * Jianping Ding [email protected] * Ruiwang Huang [email protected] 1
Center for Studies of Psychological Application, South China Normal University, Guangzhou 510631, China
2
School of Psychology, South China Normal University, Guangzhou 510631, China
3
Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou 510631, China
4
Department of Radiology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China
5
Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China
6
School of Medicine, Hangzhou Normal University, Hangzh
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