Ambulatory blood pressure abnormalities in children with migraine
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ORIGINAL ARTICLE
Ambulatory blood pressure abnormalities in children with migraine Songül Yılmaz 1
&
Sare Gülfem Özlü 1
&
Ayşegül Neşe Çıtak Kurt 2
Received: 19 March 2020 / Revised: 29 May 2020 / Accepted: 2 June 2020 # IPNA 2020
Abstract Background Although there are data showing that the frequency of hypertension increases in adults with migraine, there has been no study on this subject in children. In this study, we aimed to evaluate the presence of hypertension in children with migraine by performing ambulatory blood pressure monitoring (ABPM). Methods Thirty-seven children diagnosed with migraine and 30 healthy controls were evaluated between January 2015 and March 2016. Demographic data, clinical and laboratory features, and physical examination findings were recorded for both groups. Office blood pressure was measured for all children, and each also underwent ABPM. The two groups were compared in terms of ambulatory blood pressure parameters. Results The mean age was 13.3 and 13.1 years and the proportion of females was 73% and 60% in the migraine and control groups, respectively. Although the frequency of hypertension was not higher, abnormal ABPM patterns were found to be significantly more frequent in the migraine group (migraine, 45.9%; control, 16.7%; p, 0.018). Nighttime mean arterial blood pressure, nighttime diastolic blood pressure, and non-dipping pattern were higher in children with migraine than those in the control group (p < 0.05). Conclusions These results suggest that ambulatory blood pressure abnormalities may be present in almost half of patients with migraine. Therefore, we suggest that ABPM should be performed even if the office blood pressure measurements of children diagnosed with migraine are normal. Keywords Hypertension . Children . Migraine . Blood pressure . ABPM
Introduction Migraine is a common primary headache disorder characterized by attacks of severe headache and autonomous and neurological symptoms. Its prevalence has been reported to vary considerably, from 3 to 20%, in pediatric populations according to age and gender [1–4]. Although migraine is common and it may cause important disabilities, the underlying pathophysiological mechanisms and
* Songül Yılmaz [email protected] 1
Department of Pediatric Nephrology, Ankara Yıldırım Beyazıt University Yenimahalle Education and Research Hospital, Ankara, Turkey
2
Department of Pediatric Neurology, Ankara Yıldırım Beyazıt University Yenimahalle Education and Research Hospital, Ankara, Turkey
comorbidities are not yet fully understood. Pathological vascular reactivity, autonomic dysfunction, and ischemic vascular disorders have been reported in previous studies [5, 6]. Also, numerous studies have demonstrated that migraine is associated with cardiovascular disease (CVD) and risk factors for CVD including hypertension (HT) [5, 7–9]. There are community-based studies, including adult patients only, showing that blood pressure is higher in patients with migraine [5, 8, 10]. In contrast, some publications report th
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