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Increased creatinine: case report In a study of 192 paediatric patients (medical records reviewed between October 2016 to December 2016) in Kenya, a patient [age and sex not stated] was described, who experienced increased creatinine level while receiving antibiotic therapy with amikacin and gentamicin. The patient received first line antibiotic therapy with IV gentamicin injection bolus infusion for 30 seconds once daily along with benzylpenicillin for 2 days followed by IV amikacin injection bolus infusion for 30 seconds once daily along with ceftazidime for 6 days. The patient experienced >30% increase in creatinine levels secondary to amikacin and gentamicin [time to reaction onset not stated]. The patient’s treatment was changed to meropenem for another 7 days [outcome not stated]. Onyango EJ, et al. Evaluation of the clinical practice of aminoglycoside use in paediatric patients in Kenya: Findings and implications for lower-middle income countries. 803518049 JAC-Antimicrobial Resistance 2: no pagination, No. 1, Mar 2020. Available from: URL: http://doi.org/10.1093/jacamr/dlz087

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Reactions 28 Nov 2020 No. 1832