Aminoacid Profiling of Children with Severe Acute Malnutrition Pre and Post Nutritional Rehabilitation
- PDF / 398,040 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 93 Downloads / 188 Views
ORIGINAL RESEARCH ARTICLE
Aminoacid Profiling of Children with Severe Acute Malnutrition Pre and Post Nutritional Rehabilitation Pepu Jini1 • Anupa Prasad2 • Avinash Lomash3 • Namita Bhardwaj3 Raghavendra Singh1 • Anurag Agrawal1 • Seema Kapoor1
•
Received: 27 January 2020 / Accepted: 12 October 2020 Ó Association of Clinical Biochemists of India 2020
Abstract Malnutrition is a significant comorbidity in nearly one-third of the 8 million deaths in children under five years of age worldwide. Children with severe acute malnutrition have severely disturbed physiology and metabolism. Considering the vital importance of amino acids and the likely changes with the therapeutic diet, we aimed at evaluating these changes in children with SAM at baseline and after rehabilitation with a therapeutic diet at 14 days. Severe acute malnutrition defined as per WHO, for children between 6 months and 5 years with weight for height/length \ -3SD of WHO charts, bilateral pitting edema, and mid-upper arm circumference (MUAC) \ 1.5 cm. A total of 38 children were enrolled as cases, whereas the control group comprised of 37 children. Anthropometric measurement and estimation of amino acids in the blood were done at the baseline and after dietary rehabilitation. The individual levels of the essential and nonessential amino acids were significantly lower in the cases as compared to the controls, except for Aspartate and Threonine. The levels of amino acids increased significantly after dietary rehabilitation except for arginine, however not to the levels of those in controls. Most of the metabolites were reflective of maladaptation in SAM. Though nutritional rehabilitation of children with SAM
& Anupa Prasad [email protected] 1
Department of Pediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India
2
Biochemistry Department, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
3
Division of Genetics, Department of Pediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India
improved the levels of amino acids, these levels were still low when compared to the controls, stipulating that complete metabolic recovery may take a longer duration of time. This necessitates the continuation of nutritional rehabilitation for a longer time and regular follow up of these children to ensure better compliance. Keywords Severe acute malnutrition Amino acids Nutritional rehabilitation
Introduction Malnutrition is a significant comorbidity in nearly onethird of the 8 million deaths in children under five years of age worldwide [1]. Children with Severe acute malnutrition (SAM) have severely disturbed physiology and metabolism. The pathophysiologic mechanisms underlying the development of SAM and its clinical phenotypes are poorly understood. A metabolomic analysis of children suggested significant changes in amino acids (AA), inflammatory cytokines, fatty acids (FA), and hormones related to appetite and energy metabolism [2]. In SAM, it has been postulated
Data Loading...
