Aminophylline/salbutamol interaction
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Extreme tachycardia: case report A 45-year-old woman developed extreme tachycardia following concomitant administration of salbutamol and aminophylline for chronic obstructive pulmonary diseases [COPD; dosages not stated]. The woman, who had COPD since 10 years, was hospitalised due to dyspnoea, cough and cold. In the past, she had received salbutamol tablet 4mg twice daily and salmeterol/fluticasone [seroflo] inhaler. At admission, she was treated with dexamethasone for COPD. On the same day, several hours later, she received injection aminophylline infusion and salbutamol nebuliser, along with hydrocortisone sodium succinate [Efcortin] and salmeterol/fluticasone [Seroflo]. Additionally, she received levocetirizine/ montelukast [montelukast-LC] for cold and cough, and nasal oxygen for hypoxaemia. Subsequent examination revealed pulse rate 198 beats/minute and RR 26 breaths/minute. Pulse oximetry showed peripheral oxygen saturation of 98%, when she had HR 197 beats/minute. ECG showed extreme tachycardia [time to reaction onset not stated]. The woman therefore treated with carvedilol and isosorbide dinitrate for the extreme tachycardia and to prevent cardiovascular events. A synergistic drug interaction between salbutamol and aminophylline was determined, that resulted in the extreme tachycardia. Aminophylline infusion was therefore stopped. Hydrocortisone sodium succinate was also stopped, and the rest of the medications were continued. On day 2 of isosorbide dinitrate and carvedilol therapy, her pulse rate became normal. On day 3, an echocardiography revealed a stable cardiac status. On day 5, isosorbide dinitrate and carvedilol therapy was thus stopped. Sandhoshini Meena S. Drug interaction of aminophylline and salbutamol induced extreme tachycardia in chronic obstructive pulmonary diseases - a case report. Research 803445168 Journal of Pharmacy and Technology 12: 3896-3898, No. 8, Aug 2019. Available from: URL: http://doi.org/10.5958/0974-360X.2019.00670.X
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Reactions 11 Jan 2020 No. 1786
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